Category: 1074-82-4

Synthetic Route of 1074-82-4, These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 1,5-dibromopentane (13-k) (170.58 mL, 1.26 mol) in DMF (1.5 L) was added potassium phthalate (12-k) (78.0 g, 0.42 mol) portion-wise over 30 mm at room temperature. After complete addition, the reaction mixture was stirred at 90C for 18 h, then quenched with water (3 L) and extracted with diethyl ether (500 mL x 4). The combined organic extracts were washed with water (500 mL x 2), followed by brine (500 mL x 2) and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The residue was purified by silica gel column chromatography (60-120 mesh) using 5-10% EtOAc / hexanes to afford 14-k as an off-white solid (81 g, 65% yield).?H NMR (400 MHz, CDC13): 7.82 (dd,J= 5.5, 3.1 Hz, 2H), 7.69 (dd,J= 5.5, 3.0 Hz, 2H), 3.68 (t, J 7.2 Hz, 2H), 3.38 (t, J 6.8 Hz, 2H), 1.93-1.85 (m, 2H), 1.70 (p, J= 7.5 Hz, 2H),1.53-1.43 (m, 2H).

Statistics shows that Potassium 1,3-dioxoisoindolin-2-ide is playing an increasingly important role. we look forward to future research findings about 1074-82-4.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LADNER, Robert, D.; (340 pag.)WO2018/98207; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of Potassium 1,3-dioxoisoindolin-2-ide

Compound 4 (1.86g, 10mmol) and 1,6-b hexyl bromide (12.2g, 50mmol) in dry DMF (10 ml) and heated to 100 C, thermal insulation 12h. Then the excess is removed by reduced pressure distillation 1,6-b hexyl bromide. The silica gel column for separation and purification of the crude product (showering liquid is ethyl acetate/petroleum ether, volume ratio of 1:40), be 2.5g compound 5 (colorless powder), yield 81%.

The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Hecheng Advanced Materials Co., Ltd; Kongxiang, Fei; Huang, Da; Wanggui, Xia; Liu, Canhui; Tan, Yudong; (22 pag.)CN105461628; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, A new synthetic method of this compound is introduced below., Safety of Potassium 1,3-dioxoisoindolin-2-ide

REFERENTIAL EXAMPLE 6 To 75 g of potassium phthalimide, were added 75 g of alpha-bromo-p-xylene and 500 ml of dimethylformamide (DMF). The mixture was stirred at 100 to 110 C. for 15 hours. After cooling, the insolubles were removed by filtration and the filtrate was concentrated under reduced pressure. The residue was recrystallized from 500 ml of methanol to yield 90 g of colorless needle crystals of 4-phthalimidomethyltoluene; m.p. 120-121 C.

The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Torii & Co. Ltd.; US4598077; (1986); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Some common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, molecular formula is C8H4KNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H4KNO2

To a stirred solution of i,6-dibromohexane (12.3 rnL, 81.0 mmol) in DMF (10 mL), was added potassIum phthaiate (5.0 g, 27,0 mrnoi) portion-wise over 30 mm at room temperature. After complete addition, the reaction mixture was stirred at 90 C for 18 h, then quenched with waLer (300 mL) and extracted with diethyl ether (150 mL x 2). The combined organic extracts were washed with water (100 mL x 2), followed by brine (50 mL x 2) and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (60-120 mesh) using 5-10% EtOAc / hexanes to afford 3-i as an off- white solid (6.3 g, 76% yield). LCMS: 310.95 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1074-82-4, its application will become more common.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; SHIRUDE, Pravin S.; (258 pag.)WO2017/6282; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Potassium 1,3-dioxoisoindolin-2-ide

o a stirred solution of 1,5-dibromopentane (13-k) (170.58 mL, 1.26 mol) in DMF (1.5 L) was added potassium phthalate (12-k) (78.0 g, 0.42 mol) portion-wise over 30 min at room temperature. After complete addition, the reaction mixture was stirred at 90C for 18 h, then quenched with water (3 L) and extracted with diethyl ether (500 mL x 4). The combined organic extracts were washed with water (500 mL x 2), followed by brine (500 mL x 2) and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The residue was purified by silica gel column chromatography (60-120 mesh) using 5-10% EtOAc / hexanes to afford 14-k as an off-white solid (81 g, 65% yield).1H NMR (400 MHz, CDC13): delta 7.82 (dd, J= 5.5, 3.1 Hz, 2H), 7.69 (dd, J= 5.5, 3.0 Hz, 2H), 3.68 (t, J= 7.2 Hz, 2H), 3.38 (t, J= 6.8 Hz, 2H), 1.93-1.85 (m, 2H), 1.70 (p, J= 7.5 Hz, 2H), 1.53-1.43 (m, 2H).

The synthetic route of Potassium 1,3-dioxoisoindolin-2-ide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LADNER, Robert, D.; (244 pag.)WO2018/98208; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1074-82-4

(k) Preparation of 3-phthalimidylpropanol (compound 106) 3-Bromopropanol (4.0 g, 28.78 mmol), potassium phthalimide (8.0 g, 43.17 mmol) and potassium carbonate (4.0 g, 28.78 mmol) were added to 20 mL DMF. The reaction mixture was stirred at 70 C. for 4 hours, quenched with water and extracted with ethyl acetate. The organic layer was washed with water, saturated NaCl solution and evaporated in vacuo to a solid which was crystallized in ethyl acetate (3.5 g, 67%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1074-82-4.

Reference:
Patent; CytoMed Incorporated; US6201016; (2001); B1;; ; Patent; Cytomed, Inc.; US5681966; (1997); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1074-82-4, Application In Synthesis of Potassium 1,3-dioxoisoindolin-2-ide

Under nitrogen atmosphere, 115g of aluminum chloride was added into 750ml of methylene chloride and the slurry mass was cooled to about 0C. lOOg of cis-(+/-)-l- phenyl-3-oxabicyclo[3.1.0]hexan-2-one, compound of formula VI was added at about 0C and the reaction mixture was stirred for about 30min at about 10C. Then diethyl amine solution (125.8g of diethyl amine in 200ml of methylene chloride) was added to the reaction mixture at about 10C to about 15C over a period of 45min and the reaction mixture was stirred for about 60min at about 10C to about 15C. Then 1800ml of water was added to the reaction mixture at about 10C to about 20C over a period of about 30min and stirred for about 2h at about room temperature. 25g of Hyflo was added and stirred for about lOmin. The reaction mixture was filtered through Hyflo bed and the Hyflo bed was washed with 100ml of methylene chloride. The organic layer was separated and taken into a clean container. The aqueous layer was again extracted with 300ml of methylene chloride; where a second organic layer was obtained. The combination of the organic layers was washed with 500ml of water followed by washing with 500ml of 10% aqueous sodium chloride solution, then the organic layer was treated with 50g of sodium sulphate. The organic layer was taken into a round bottomed flask and was cooled to 15C and 95.75 gm of thionyl chloride was slowly added at about 15C to about 20C over a period of about 30min and the reaction mixture was stirred for about 30min at about 15C to about 20C. The reaction mass was cooled to about 0C and 319g of potassium phthalimide was added, the temperature was raised to about 40C to about 45C and stirred at same temperature for about lh, then the reaction mass was cooled to about 10C to about 15C. Then 2.5 liters of 4% aqueous sodium hydroxide solution was added to the reaction mixture at about 10C to about 20C and stirred for about 30min. The aqueous and organic layers were separated and the organic layer was washed 4 times with 700ml each of water and solvent of the organic layer was distilled out completely under vacuum. 200ml of methanol was added to the residue mass at about 35C to about 40C and stirred for about lOmin. Then methanol was distilled out completely under vacuum. Then, 600ml of methanol was added to the residue mass and the temperature was raised to about 65 C and stirred for about 30min. The reaction mixture was cooled to about 20C to about 25C and stirred for about 2h. The precipitated product was filtered and washed with 100ml of chilled methanol. The wet cake was added to 1500ml of water and the slurry was stirred at about 55C to about 60C for about 2h. The solid was filtered at about the same temperature and washed with 500ml of water. The wet cake was added to 350ml of acetone and heated about reflux temperature, then 5g of activated charcoal was added to the clear solution and maintained reflux for about 30min. The reaction mass was filtered through Hyflo bed and the bed was washed with 30ml of acetone. Slowly the clear solution was cooled to about room temperature over a period of lh. Solid was precipitated out and the slurry was maintained for about lh at about room temperature. The solid was filtered out and washed with 50ml of chilled acetone. The compound was dried at about 50C to about 55C for about 15h to yield 1 lOg of the title compound.Purity by HPLC: 99.2%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Potassium 1,3-dioxoisoindolin-2-ide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLENMARK GENERICS LIMITED; JAMBUKAR, Nagambar Genuji; GHARPURE, Milind; SINARE, Sudam Nanabhau; THOMBRE, Pravin Chhaburao; KHAN, Mubeen Ahmed; WO2011/158249; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Synthetic Route of 1074-82-4, These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a dried flask, to a solution of chloroacetone, (10 g, 108 mmol) in DMF (100 mL) was added potassium phthalimide (22 g, 118 mmol) with constant stirring (potassium phthalimide was not completely soluble in DMF). The reaction was stirred at room temperature for 16 h and monitored by TLC. After the reaction was complete, the reaction mixture was poured into water (2500 mL). A white precipitate formed, which was collected by filtration, washed with water until colourless, and dried to afford 21.6 g (99.0% yield) N-acetonyl phthalamide (3). 1H NMR (CDCl3, 600 MHz) delta 7.88-7.87(dd, 2H, J1 = 2.7 Hz, J2 = 5.4 Hz), 7.76-7.75 (dd, 2H, J1 = 2.7 Hz, J2 = 5.4 Hz), 4.51 (s, 2H), 2.27 (s, 3H).

The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; He, Ying-Chun; Ren, Zhen-Xing; Zhao, Xue-Feng; Zhang, Yong-Bin; Wang, Jun-Hong; Chao, Jian-Bin; Wang, Meng-Liang; Tetrahedron; vol. 75; 36; (2019);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 1074-82-4,Some common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, molecular formula is C8H4KNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 100 ml two-necked round bottom flask, 5.08 g phthalimide potassium salt (27.4 mmol) and 30 ml allylbromine (26.6 mmol) were dissolved in 40 ml DMF under the nitrogen atmosphere. The mixture was stirred for half an hour at 55 ¡ãC for 17 h, then 200 ml H2O was added and the mixture was?extracted with CH2Cl2 (80 ml ¡Á 3). The combined organic phase was dried over anhydrous Mg2SO4. After the removal of solvent under reduced pressure, the crude product was purified by column chromatography on silica gel with CH2Cl2 as the eluent, the collected pale?yellow oil was determined to be the desired product 2-allylisoindoline-1,3-dione (4.87 g, 95percent yield). 1H NMR (400 MHz, CDCl3): delta 7.90 (m, 2H), 7.76 (m. 2H), 5.93 (m, 1H), 5.26 (m, 2H), 4.34 (d, J = 8.0 Hz, 2H). 13C NMR (101 MHz, CDCl3): delta 167.95, 134.04, 132.26, 131.67, 123.37, 117.84, 40.14.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Potassium 1,3-dioxoisoindolin-2-ide, its application will become more common.

Reference:
Article; Wu, Huarui; Zheng, Chaoyue; Chen, Naiwu; Zhu, Jie; Gao, Deqing; Tetrahedron Letters; vol. 58; 16; (2017); p. 1576 – 1578;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 1074-82-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1074-82-4 as follows.

To a stirred solution of 1,5-dibromopentane (13-k) (170.58 mL, 1.26 mol) in DMF (1.5 L) was added potassium phthalate (12-k) (78.0 g, 0.42 mol) portion-wise over 30 min at room temperature. After complete addition, the reaction mixture was stirred at 90C for 18 h, then quenched with water (3 L) and extracted with diethyl ether (500 mL x 4). The combined organic extracts were washed with water (500 mL x 2), followed by brine (500 mL x 2) and dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude. The residue was purified by silica gel column chromatography (60-120 mesh) using 5-10% EtOAc / hexanes to afford 14-k as an off-white solid (81 g, 65% yield). 1H NMR (400 MHz, CDC13): delta 7.82 (dd, J= 5.5, 3.1 Hz, 2H), 7.69 (dd, J= 5.5, 3.0 Hz, 2H), 3.68 (t, J= 7.2 Hz, 2H), 3.38 (t, J= 6.8 Hz, 2H), 1.93-1.85 (m, 2H), 1.70 (p, J= 7.5 Hz, 2H), 1.53-1.43 (m, 2H).

According to the analysis of related databases, 1074-82-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; (500 pag.)WO2018/98206; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem