Category: 169037-23-4

Electric Literature of 169037-23-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 169037-23-4 as follows.

General procedure: General method: The Schiff bases were obtained by adding an ethanolic solution of the hydrazinyl component to the solution of the keto component in equimolar amounts, refluxing the mixture in the presence of catalytic amounts of acid. If not indicated otherwise, purification was carried out by recrystallization. Carbazides were prepared by adding an equimolar amount of hydrazine to the methanolic solution of the respective isothiocyanate [53]. For the picolinylidene derivatives with ethyl group in 5-position of the pyridine moiety (2e, 2k), 5-Ethylpicolinaldehyde was prepared from 5-ethyl-2-methyl-pyridine as reported previously [13,115]. The reaction of 5-trifluoromethoxyisatin (50mg, 0.22mmol) with N-(4-methoxyphenyl)hydrazinecarbothioamide C-1 (43mg, 0.22mmol) in ethanolic solution under HCl-catalysis resulted in a yellow fluffy precipitate, which was identified as the product in 70% yield (65.7mg, 0.16mmol). 1H NMR (500MHz, DMSO-d6): delta=12.60 (s, 1H), 11.36 (s, 1H), 10.78 (s, 1H), 7.78 (s, 1H), 7.49-7.41 (m, 2H), 7.41-7.31 (m, 1H), 7.02 (d, 1H, 3J(H,H)=5.0Hz), 7.01-6.95 (m, 2H), 3.78 (s, 3H). 13C NMR (126MHz, DMSO-d6): delta=176.6, 162.7, 157.5, 143.5, 141.2, 131.1, 130.9, 127.3 (2C), 124.0, 121.5, 120.7 (d {121.19, 119.15}, 1J(C,F)=255.7Hz), 114.4 (2C), 113.6, 112.1, 55.3. Anal. Calcd. for C17H13N4SO3F3: C: 49.76; H: 3.19; N: 13.65. Found: C: 49.61; H: 3.477; N: 13.53

According to the analysis of related databases, 169037-23-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pape, Veronika F.S.; Toth, Szilard; Fueredi, Andras; Szebenyi, Kornelia; Lovrics, Anna; Szabo, Pal; Wiese, Michael; Szakacs, Gergely; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 335 – 354;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H4F3NO3

General procedure: A mixture of 5,6-dimethoxy-2-[(E)-1-arylmethylidene]-1-indanone (1, 0.364 mmol), thiazolidine-4-carboxylic (3, 0.364 mmol) and 1-morpholinoindoline-2,3-dione (2,0.364 mmol) was dissolved in methanol (1 mL) and irradiated for 2-3.5 min in a CEM microwave synthesizer (100 0C, 100 W). After completion of the reaction as evident from TLC, the mixture was poured into water. The precipitated solid was filtered and washed with water to afford the products 4a-i which was purified by recrystallisation.

The synthetic route of 5-(Trifluoromethoxy)indoline-2,3-dione has been constantly updated, and we look forward to future research findings.

169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-(Trifluoromethoxy)indoline-2,3-dione

Information Example 2: 5-Trifluoromethoxy-1H-indole Lithium aluminum hydride (10.4 mL,1M in THF, 10.4 mmol) was added to a solution of 5-trifluoromethoxyistatin (0.8 g, 3.45 mmol) in THF at room temperature and the mixture was refluxed overnight. The reaction mixture was cooled, and Na2SO4·10H2O was added very carefully portionwise, followed by ethyl acetate. The reaction mixture was then filtered, and the filtrate was evaporated. The residual oil was purifed by column chromatography with ethyl acetate in hexanes (2:98) to yield 5-trifluoromethoxy-1H-indole (0.162 g, 23%).

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H4F3NO3

General procedure: A mixture of beta-nitrostyrenes, isatin and tyrosine (1:1:1) was stirredunder heating at 100 C for 1 h in [bmim]Br (200 mg). After the reaction was completed, 10 mL of ethyl acetate was added to the reaction mixture and stirred for 15 min. The organic layer was separated, washed with water, and dried. The cycloadduct was further purified using hexane: ethyl acetate (3:2 v/v) as eluent employing column chromatography technique. After extraction of the cycloadduct, [bmim]Br wasdried under vacuum at 80 C for 2 h to exclude any water trapped from moisture and reused for subsequent runs.

The synthetic route of 5-(Trifluoromethoxy)indoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Electric Literature of 169037-23-4,Some common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, molecular formula is C9H4F3NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A lL, four-necked, jacketed flask equipped with a thermocouple, nitrogen inlet/bubbler, condenser and a mechanical stirrer was charged with 50.0 g of 5-trifluoromethoxyisatin (4) (commercially available from, for example, Aldrich), and 25 g of Amberlite FPC22H resin. The resin was distilled over toluene (200ml/100g) three times and dried at 40 0C under vacuum overnight. A quantity of 43 ml of HC(OEt)3 and 400 ml of absolute ethanol was used. The reaction mixture was heated to reflux. The batch temperature was 76.5 0C and the jacket was set at 90 0C. The mixture was held at reflux and a quantity of 21.5 ml OfHC(OEt)3 was charged at 90 minute, 180 minute, and 300 minute intervals. The mixture was held for another 2 hrs and the batch was cooled to 20 0C and filtered through a celite bed. The solution was collected and distilled to dryness under vacuum. The crude residue was re-slurried in 80 ml of 1 : 10 EtO Ac/heptane and stirred at 0 0C for an hour and filtered to collect the product. Intermediate (7) was obtained in 80% yield and >99% HPLC purity.

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 169037-23-4, name: 5-(Trifluoromethoxy)indoline-2,3-dione

Step c: 5 -(trifluoromethoxy)indo lin-2-one[0514] A solution of 5-(trifluoromethoxy)indoline-2,3-dione (0.2 g, 0.87 mmol) in hydrazine hydrate (85%, 2.0 mL) was heated at 130C for 4 h. After the mixture was cooled to room temperature, it was poured into ice-water (10.0 mL). The resulting mixture was adjusted to pH=2 and stirred at room temperature for 2 d. The precipitate was collected by filtration, washed with water and dried under vacuum to give 130 mg of the title compound (69%> yield).

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(Trifluoromethoxy)indoline-2,3-dione

General procedure: N-(4-Sulfamoylphenyl)hydrazinecarbothioamide (2) (3.5mmol) was added to a solution of 1H-indole-2,3-diones 3a-m (3.5mmol) in ethanol (20mL). After addition of a drop of concentrated sulfuric acid, the mixture was refluxed on a water bath for 4h. The product formed after cooling was filtered and washed with ethanol or recrystallized from ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 169037-23-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of indoline-2,3-dione 1 (1mmol), l-tryptophan (2a) or l-histidine 2b (1mmol) and (E)-(2-nitrovinyl)benzene 3 (1.1mmol) was heated while stirred in [bmim]Br as the reaction medium (3mL) for 1hat 100C. After completion of the reaction (TLC), EtOAc (5mL) was added and the reaction mixture was stirred for 10min. This treatment was repeated and the combined ethyl acetate layers were removed in vacuo. The crude product was purified by recrystallization of the residue from EtOH (compounds 4) or by column chromatography (compounds 5). After extraction of the product, the ionic liquid was dried under vacuum at 80C for 2h to eliminate any water and could be reused for subsequent runs of the reaction.

The chemical industry reduces the impact on the environment during synthesis 5-(Trifluoromethoxy)indoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H4F3NO3

General procedure: Sulfonated-beta-cyclodextrin (beta-CD-SO3H) (76 mg, 0.06 mmol) was dissolved in water (5 mL) at RT by stirring to get the clear solution in 50 mL round bottom ask. Further, isatin 2 (0.31 mmol) and tryptamine 1a/isotryptamine 1b (0.31 mmol) were added to the solution under constant stirring and mixture was heated at 80 C for 8-12 h. The progress of the reaction was monitored by TLC. After completion of reaction, it was cooled to room temperature, water was added to it. The aqueous phase was extracted with ethylacetate. The organic extracts were combined, washed with brine and dried over sodium sulfate. The solvent was evaporated in vacuo and the crude product obtained was puried by column chromatography using chloroform/methanol (99:1) as an eluent furnishing the product. The spectral and analytical data of all the reported products is consistent with the previous (6c,d,f) reports.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 169037-23-4.

Reference of 169037-23-4,Some common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, molecular formula is C9H4F3NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) Step 1 Aqueous sodium hydroxide (0.0888 g, 2.22 mmol, 2 mL) was heated to 50C, and added with 5-trifluoromethoxyisatin (0.500 g, 2.16 mmol). The mixture was stirred at 50C for 1 hour, and then cooled on ice. The reaction mixture was added with sodium nitrite (0.149 g, 2.16 mmol), and then added dropwise with a solution of concentrated sulfuric acid (0.413 g, 4.21 mmol) in ice-cooled water (3.5 mL), and the mixture was stirred for 1 hour under ice cooling. Then, the mixture was added dropwise with an ice-cooled solution of tin(II) chloride dihydrate (1.17 g, 5.18 mmol) in concentrated hydrochloric acid (1.7 mL). The mixture was stirred overnight at room temperature, and then filtered to obtain a pale brown solid (0.638 g).

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi; EP2565192; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem