Category: indolines-derivatives

We’ll be discussing some of the latest developments in chemical about CAS: 71294-07-0. Synthetic Route of 71294-07-0

Step 1 5,6-difluoro-3-methyl-1,3-dihydro-indol-2-one 1.5 g (9.0 mmol) 5,6-difluoro-1,3-dihydro-indol-2-one were stirred with 1.0 g Raney nickel in 50 mL methanol 3 h at 200 C. in an autoclave. The catalyst was filtered off and the filtrate was concentrated to dryness by rotary evaporation. Yield: 1.6 g (99% of theory) ESI-MS: m/z=184 (M+H)+

In the meantime we’ve collected together some recent articles in this area about 71294-07-0 to whet your appetite. Happy reading!

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/195954; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Application In Synthesis of 5,7-Dimethylindoline-2,3-dione

45. A. SYNTHESIS OF 5, 7-DIFNETHYL-IH-INDOLE To solution of 5, 7-dimethyl-lH-indole-2, 3-dione in tetrahydrofuran at 0 C was added 1. 0 M solution of borane-tetrahydrofuran complex in tetrahydrofuran (40 mL). After stirred at room temperature overnight, a 5% HCl solution was added to the mixture and it was stirred 20 minutes. It was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and evaporated to dryness to afford the title compound as oil.

Hope you enjoy the show about 39603-24-2.

Reference:
Patent; SALMEDIX, INC.; WO2005/33112; (2005); A2;,
Indoline – Wikipedia,
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Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 2058-72-2

General procedure: DABCO (0.112 g, 1.00 mmol) was added to a solution of 2a (0.08 g, 0.5 mmol), phenol (0.094 g, 1.00 mmol) and 1a (0.147 g, 1.00 mmol) in acetonitrile (0.5 mL), and the reaction was kept for 2 days. The reaction mixture was then directly subjected to column chromatography (EtOAc/Hexane, 3:10) to obtain the product 3aa as a yellow solid (0.142 g) at 92% yield.

The chemical industry reduces the impact on the environment during synthesis 2058-72-2. I believe this compound will play a more active role in future production and life.

Reference:
Article; Singh, Radhey M.; Bharadwaj, Kishor Chandra; Tiwari, Dharmendra Kumar; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2975 – 2980;,
Indoline – Wikipedia,
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Safety of N-Phthaloylglycine, The chemical industry reduces the impact on the environment during synthesis 4702-13-0, name is N-Phthaloylglycine, I believe this compound will play a more active role in future production and life.

(a) Preparation of 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride STR10 A solution of 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid (7.00 g) and thionyl chloride (12 mL) was stirred at reflux under nitrogen for one hour. The thionyl chloride was distilled from the reaction, and the resulting crude product was further purified by distillation via a kugelrohr apparatus (BUCHI, Flawil, Switzerland). [Bp: 160-180 C. (oven temperature) at 10 mm Hg.]The yield of the title compound was 6.88 grams (90.2%). The structure of the title compound, and of all of the compounds synthesised in each of the subsequent examples, was confirmed by 1 H NMR.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; G. D. Searle & Co.; US5212169; (1993); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Recommanded Product: 15362-40-0,Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations.

27.8 g (0.1 mol) of 1-(2,6-dichlorophenyl)-2-indanone (II) was dissolved in 100 mL of toluene.Then add 5g of triethylbenzylammonium chloride (TEBAC),50 mL of 30% sodium hydroxide solution, stirred and refluxed for 10 h.Stop the reaction,Add 80mL of water,Change to a distillation unit.Toluene is removed by azeotropic distillation,The residual liquid was allowed to stand, cooled, and a large amount of solid was precipitated.filter,It was recrystallized from 100 mL of water and decolorized with activated carbon to give a white solid (26.6 g).

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Chinese People’s Liberation Army Fanghua College; Tian Xingtao; Ren Lijun; Xiang Yulian; Fan Qiping; Huang Zhiping; Chen Hong; Zhou Lei; (8 pag.)CN103145574; (2018); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, A new synthetic method of this compound is introduced below., Electric Literature of 102359-00-2

The above material was dissolved in methanol (50 mL) and formic acid (5 miL) and hydrogenated over Pd/C (0.40 g) at elevated hydrogen pressure (50 psi) for 16 h. The reaction mixture was filtered through a plug of celite (10 g), the celite was washed with methanol (2X20 ML), the combined filtrates were evaporated to dryness, dissolved in H20 (20 mL), and re-evaporated. The resulting residue was dissolved in N, N-DIMETHYLFORMAMIDE (5 mL), and added in one portion to the previously prepared suspension of 2-oxoindoline-5-carboxylic acid (0.53 g, 3 MMOL), O-(BENZOTRIAZOL-L-YL)-N, N, N, N-TETRAMETHYLURONIUM tetrafluoroborate (1.1 g, 3.6 mmol), 1-HYDROXYBENZOTRIAZOLE (0.486 g, 3.6 mmol) and N,N-diisopropylethylamine (1.7 g, 12 mmol) in acetonitrile (10 ML) and N,N-dimethylformamide (10 mL). The mixture was stirred overnight, the solvents were removed in vacuo, and the residue was purified on a silica gel column using chloroform/methanol, (10: 1), then CHLOROFORM/METHANOL/AQUEOUS ammonia, (100: 10: 1), as the eluent. The semi-solid crude material was again subjected to silica gel chromatography using chloroform/methanol/aqueous ammonia, (150: 10: 1), as the eluent to afford 0.20 g (19% yield) the title compound as yellow foam: MS (ES) M/Z 367 (M++1).

This is the end of this tutorial post, and I hope it has helped your research about 102359-00-2.

Reference:
Patent; ASTRAZENECA AB; WO2005/27823; (2005); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 19727-83-4, name is 6-Nitroindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19727-83-4, Product Details of 19727-83-4

To a solution of 6-nitroindoline (1.00 g, 6.09 mmol) and pyridine (1.48 mL, 18.27 mmol) in DCM (3 mL) was added a solution of t- butylsulfinyl chloride (0.751 mL, 6.09 mmol) at 0 C under Argon. The mixture was warmed to room temperature and stirred overnight. The reaction mixture was diluted with EtOAc (50 mL) and washed with HC1 (1 M aq. solution, 1 x 50 mL), water (1 x 50 mL), and brine (1 x 50 mL). The organic layer was dried (Na2S04) and concentrated under reduced pressure. The resulting residue was triturated using EtOAc/hexanes to provide the title compound as a dark yellow solid (1.252 g, 77%). Mp: 108 C (dec). NMR (400 MHz, CDCb) delta: 7.82 (dd, / = 8.1, 2.1 Hz, 1H), 7.67 (d, / = 2.1 Hz, 1H), 7.25 (d, / = 8.1 Hz, 1H), 4.36 (td, / = 10.5, 6.8 Hz, 1H), 3.60 (td, / = 10.5, 6.8 Hz, 1H), 3.30 (dddd, / = 17.3, 10.5, 6.8, 0.8 Hz, 1H), 3.17 (dddd, / = 17.3, 10.5, 6.8, 0.8 Hz, 1H), 1.34 (s, 9H). HPLC-MS (ESI+): m/z 559.3 [70%, (2M+Na)+], 291.2 [100%, (M+H)+].

This is the end of this tutorial post, and I hope it has helped your research about 19727-83-4.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22190-33-6 as follows. HPLC of Formula: C8H8BrN

REFERENCE EXAMPLE 8 1-boc-5-Bromoindoline 5-bromoindoline (10 g) was added in one portion to molten Boc-anhydride (11.6 g) at 30-40 C. Immediate effervescence was followed by the formation of a solid cake which was triturated with pentane to give the title compound (15 g) as a white powder.

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Reference:
Patent; Aventis Pharma Ltd.; Aventis Recherche Developpment; US6608084; (2003); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7147-90-2 as follows. Application of 7147-90-2

2-chloro-6-bromoquinoline (240 mg, 1 mmol), triethylene diamine (224 mg, 2 mmol)5-chlorophthalimide (360 mg, 2 mmol), sodium carbonate (210 mg, 2 mmol),Acetonitrile (2 ml) was added to the dry reaction tube and suspended in an oil bath at 120 C for 24 h.After cooling the reaction system, 15 ml of water was added and the aqueous phase was extracted three times with 30 ml of ethyl acetate,The organic phases were combined and the solvent was evaporated under reduced pressure to give 378 mg of colorless solid2- (2- (4- (6-bromoquinolyl) 2-piperazinyl) 1-ethyl) -5-chloroisoindole-1,3-dione,The yield was 76%.

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Reference:
Patent; Yichun University; Zhu Qiming; Chen Mingwei; (20 pag.)CN106317021; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation., Electric Literature of 141452-01-9

Preparation of Compound 29, 1-tert-butyl 5-methyl indoline-1,5-dicarboxylate[0044] Di-tert-butyl dicarbonate (0.489 g, 2.24 mmol), followed by triethylamine (0.315 mL, 2.24 mmol) was added to a solution of Compound 28 (0.328 g, 1 .85 mmol) in dry DCM (5.8 mL) and the reaction mixture was stirred at rt for 26 hrs, concentrated. The residue was dissolved in EtOAc and washed with water (1 x), brine (1 x), dried (MgS04), filtered and concentrated. The crude material was recrystallized from hot EtOH to afford the title compound (373 mg, 73%) as a white solid. 1H NMR (500 MHz, CDCI3) delta 7.88 (d, J = 7.6 Hz, 1 H), 7.82-7.79 (m, 1 H), 4.02 (t, J = 8.7 Hz, 2H), 3.88 (s, 3H), 3.14 – 3.09 (m, 2H), 1 .57 (br s, 9H). Note that there also appears to be 2 extremely broad and weak singlets centred at 7.85 and 7.50 ppm which may be the missing aromatic CH. LRMS (ESI+): 178.09 (loss of Boc) and very weak 278.15

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research.Keep reading other articles of Methyl indoline-5-carboxylate.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem