Category: indolines-derivatives

25369-31-7, name is 7-Nitroindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H6N2O3

To a solution of 7-nitroindolin-2-one in methanol (1.0 gm/60 ml), added Pd/C (300 mg, 30 wt %). H2 gas maintained with pressure using hydrogen gas balloon, solution stirred for 4 hours at RT. The catalyst was removed by filtration over celite. The filtrate was concentrated in vacuo to give crude product, which was washed with diethyl ether to afford compound 7-aminoindolin-2-one; YD: 76.77%; mp:248-251 C.; R1 0.6 (CHC13:MeOH:: 9.0:1.0). 1H NMR (DMSO-d6) 200 MHz, delta 3.382 (s, 2H), 4.794 (s, 2H), 6.453- 6.498 (m, 2H), 6.673 (t, J=8.0 Hz, 1H), 9.906 (s, 1H). MS (ESI): mlz 146.8 [M-H]-.

The synthetic route of 25369-31-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 153744-36-6, name is Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate, A new synthetic method of this compound is introduced below., Formula: C12H11NO5

General procedure: tert-Butyl(2-iodoethoxy) diphenylsilane (1.4 eq) andAg2CO3 (4.0 eq) were added to a suspension of the aminoacid derivative (1.0 eq) in toluene (10.0 ml). The reactionmixture was stirred in a pressure tube at 120 C until TLCindicated complete consumption of the amino acid derivative,cooled to rt, filtered through a paper filter and reducedin vacuum. The residue was purified by flash columnchromatography on silica (eluent: pentane/Et2O 7:3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84764-41-0, name is 2-(2-(2-Methyl-1,3-dioxolan-2-yl)ethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., HPLC of Formula: C14H15NO4

20 g of 2- (2- (2-methyl-1,3-dioxolan-2-yl) ethyl) isoindoline-1,3-dione was dissolved in 200 ml Liter of methanol, and to the inside of a 4.60 grams of 98% purity of hydrazine hydrate. The reaction was stirred for 12 hours under reflux. reaction After the end of the reaction, the reaction system was allowed to stand at room temperature and suction filtered. The filtrate was dried under reduced pressure to give crude 2- (2-methyl-1,3-Dioxolan-2-yl) ethylamine was used directly in the next step in a yield of 99%.

The synthetic route of 84764-41-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 161596-47-0, name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 161596-47-0, Recommanded Product: 161596-47-0

((S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.56g, 22.46mmol, 1.3eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77g, 17.29mmol) were dissolved in isoamyl acetate (70mL) respectively, and heated to 120C. Then magnesium chloride (0.12g, 1.28mmol) was added, the mixture was reacted for 4h, white solid was obtained by filtration (6.97g, yield:95.5%). ESI-MS(m/z): 422(M+H), 444(M+Na); 1HNMR(400MHz, CDCl3) delta: 3.74(m, 2H), 3.94(m, 4H), 4.10(m, 2H), 4.32(s, 2H), 4.98(m, 1H), 7.34(d, 2H), 7.56(d, 2H), 7.75(m, 2H), 7.88(m, 2H); HPLC: 98.82%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Related Products of 120266-80-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120266-80-0, name is 5-Aminoindolin-2-one hydrochloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5-lsothiocyanato-1 ,3-dihydro-indol-2-oneTo a stirring solution of 5-amino- ,3-dihydro-indol-2-one hydrochloride (2 g, 10.83 mmol) and diisopropylethylamine (4.19 g, 32.49 mmol) in drydichloromethane (100 ml) at 0 C under N2, thiophosgene (1.49 g, 10.83 mmol) in dichloromethane is added dropwise and stirred for 30 minutes. The reaction mixture is quenched with water (100 ml) and the layers are separated, the organic layer is washed with water (50 ml X2) and dried over anhydrous MgS04 to get the product as brown crystalline solid (2.03 g, 99.02 %); TLC: chloroform/methanol (9.5/0.5) Rf- 0.5;1H-NMR (400 MHz, DMSO-d6): delta [ppm] 10.60 (s, 1H), 7.31 (s, 1 H), 7.25 (d, J = 7.88 Hz, 1H), 6.82 (d, J = 8.24 Hz, 1 H), 3.50 (s, 2H

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Aminoindolin-2-one hydrochloride, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106352-01-6, name is 3-((1,3-Dioxoisoindolin-2-yl)methyl)benzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-((1,3-Dioxoisoindolin-2-yl)methyl)benzoic acid

To 3-(1 ,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid (300 mg, 1.066 mmol) in DCM (1 mL9 are added at O0C triethylamine (164 uL, 1.173 mmol) and ethylchloroformate (112 uL, 1.173 mmol). After stirring at O0C during 15 min and filtration, the obtained solution is added at 0C to NaBH4 (61 mg, 1.599 mmol) in water (400 uL) before stirring at 00C during 30 min and at rt during 2h. The solution is acidified to pH 3 with an aqueous 1N HCI solution, extracted with ethylacetate, the organic phase is dried and evaporated to give a crude compound before purification by flash chromatography on silica gel (eluent: cyclohexane/ethyl acetate 9/1 to 1/1) to yield a colorless gum. TLC, Rf (cyclohexane/ethyl acetate 1/1) = 0.15.

The synthetic route of 106352-01-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 16800-68-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16800-68-3, name is 1-Acetylindolin-3-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 1a (35 mg, 0.2 mmol) and 2a (52.4 mg,0.4 mmol) in DCE (3 mL) was added iodine (10 mg, 0.04 mmol). The reaction mixture was heated at 80 C for 24 h, then cooled to room temperature and quenched with saturated sodium thiosulfate. The mixture was extracted with CH2Cl2, the combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel to afford title compound.

The synthetic route of 1-Acetylindolin-3-one has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102359-00-2, Computed Properties of C9H7NO3

2-Oxo-2,3-dihydro-lH-indole-5-carboxylic acid (7 g, 39 mmol) is dissolved together with benzylalcohol (4.2 mL, 39 mmol) and 4-lambda/,lambda/-dimethylaminopyridine (1 g, 7.9 mmol) in 70 mL DCM and cooled in the ice bath. Then l-ethyl-3-(3-dimethylaminopropyl)carbo- diimide (8.3 g, 43 mmol) is added and the mixture is heated to RT for 12 h. After evaporation of the solvent the residue is taken up in a little methanol and combined with 1 N hydrochloric acid (200 mL). The precipitate formed is filtered and dried. Yield: 6.9 g (65 %) (A86).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Oxoindoline-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 603-62-3, name is 3-Nitrophthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 603-62-3, Recommanded Product: 3-Nitrophthalimide

Step 1) Synthesis of 2-carbamoyl-6-nitrobenzoic acid This moiety was synthesized using the following protocol. To a solution of potassium hydroxide (6.44 g, 114.4 mmol) in water (200 mL), was added 3-nitrophalimide (10; 10 g, 52 mmol) in portions at 0 C. The suspension was stirred at 0 C. for 3 hours, and then heated to 30 C. for 3 hours. To the solution, was added HCl (40 mL, 6N). The resulting suspension was cooled to 0 C. for 1 hour. The suspension was filtered and washed with cooled water (2*20 mL) to give 2-carbamoyl-6-nitrobenzoic acid (11; 8.5 g, 77%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitrophthalimide, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 18711-13-2,Some common heterocyclic compound, 18711-13-2, name is 4,7-Dichloroindoline-2,3-dione, molecular formula is C8H3Cl2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4,7-Dichloroisotin (4.26 g, 19.7 mmol, 1 equiv, Alfa Aesar lot 10173559) and MeOH (70 mL, 16.4 vol) were charged to a 250-mL, three-neck, round-bottom flask equipped with nitrogen line, overhead mechanical stirrer, and a temperature probe. Diethylamine (0.43 g, 0.30 equiv, Sigma- Aldrich lot SHBD5313V) was added over 1 min via syringe (the slurry becomes dark red). l-[4-(Methylamino)phenyl]ethanone 3 (11.4 g, 3.9 equiv, Sigma- Aldrich lot 01129HHV) was added in portions via a plastic funnel, over 15 min. The funnel was rinsed with MeOH (2 x 15 mL, 7.0 vol). The reaction was stirred at ambient temperature (approximately 18-20 C) and periodically sampled for in-process control (IPC) by HPLC. After 40 h of reaction, additional diethylamine was charged to the reaction via syringe (0.16 g, 0.11 equiv) and the stirring continued at ambient temperature. After 64 h, a light slurry formed. Additional diethylamine was charged to the reaction via syringe (0.13 g, 0.09 equiv) and the stirring continued at ambient temperature. After 92 h of reaction IPC by HPLC analysis showed 2.1% AUC of isatin 1 present in the reaction mixture. Additional diethylamine was charged to the reaction via syringe (0.07 g, 0.05 equiv) for a total of 0.55 equiv of base and the stirring continued at ambient temperature over the weekend. After a total of seven days, the reaction was concentrated under reduced pressure (water bath <40 C), the solid residue was dissolved in a mixture of dichloromethane (450 mL) and MeOH (50 mL) at 30 C, and adsorbed over 20 g of silica gel. Purification was carried out in a Combiflash CompanionTM XL system with a RediSep disposable flash 220 g silica gel column (catalog 69-2203-422). Elution of the residual starting material 3 was accomplished with dichloromethane (approximately 20 column vol, while the product TK- 202 was eluted with 10% methanol in dichloromethane. The product containing fractions, where product had already started to precipitate, were combined in two different lots and partially concentrated under reduced pressure. The resulting slurries were filtered and the solid cakes were washed with MeOH to afford two fractions that were dried under high vacuum at ambient temperature for 24 h, then 50 C for 24 h, to afford lot BIO-W-30-17 and lot BIO-W-30-18. The filtrate from both crystallizations were combined and subjected to a second chromatographic purification (on a 40-g RediSep Gold column, catalog 69- 2203-347) using a gradient from dichloromethane to 5% methanol in dichloromethane for elution. The product containing fractions (purity higher than 99% AUC by HPLC) were combined and the product was allowed to precipitate over 2 h. The solid was filtered off, washed with methanol, and dried under high vacuum for 24 h at 50 C to afford lot BIOW- 30-19. A second set of fractions containing product of approximately 95% AUC purity by HPLC were combined, the solid was filtered off, re-dissolved in dichloromethane, and added 20% methanol to precipitate overnight. The precipitated TK-202 was filtered and washed with methanol, then dried under high vacuum for 24 h at 50 C to afford lot BIO-W-30-16. The total combined weight of 5.99 g corresponds to 83% yield of compound. Solid is off- white (with a very pale peach to tan shade). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dichloroindoline-2,3-dione, its application will become more common.