Category: indolines-derivatives

Application of 161596-47-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Gouda, Moustafa A., introduce new discover of the category.

Ascorbic Acid as an Eco-friendly Catalyst for the Efficient Synthesis of Bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in Aqueous Media

One pot, multi component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) (3a-1) and 3, 3-bis(5-hydroxy-3-methyl-1-phenyl- 1H-pyrazol-4-yl)-5-substituted indolin-2-ones (5a-c), respectively. This protocol provides several advantages such as environmental friendliness, excellent yields, and simple workup procedure

Application of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, HPLC of Formula: C22H19N3O6, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Mohamed, Asmaa H., once mentioned the new application about 446292-08-6.

Novel series of dihydroquinolindihydro-spiro[indoline-3,6 ‘-[1,3]thiazine]-5 ‘-carbonitrile derivatives

A series of new spiro[indoline-3,6’-[1,3]thiazines] were synthesized in modest yields by refluxing of substituted (1,2-dihydroquinolin-3-yl)-methylene)hydrazinecarbothioamides with 2-(2-oxoindolin-3-ylidene)malononitrile in pyridine as a solvent. The structure assignment of all obtained products has been confirmed by H-1, C-13 NMR, 2D-NMR, N-15 NMR spectroscopy in addition to elemental analyses. The possible mechanism for the reaction is also discussed. (C) 2020 Published by Elsevier B.V.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 446292-08-6 help many people in the next few years. HPLC of Formula: C22H19N3O6.

Adding a certain compound to certain chemical reactions, such as: 603-62-3, name is 3-Nitrophthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 603-62-3, HPLC of Formula: C8H4N2O4

Example 1 (best mode):; A solution of NaOH (2.0 mole) having a strength of 1 5% by weight was cooled to a temperature of 25C. Then 1 .0 mole of 3-nitro-phthalimide was added portionwise under stirring. While maintaining the temperature at 25-30C, 1 .2 mole solution of 12% strength sodium hypochlorite was added portionwise. During addition, the pH of the reaction mass was kept at pH 12.0 with aqueous sodium hydroxide with a concentration of of 15% by weight. After stirring for 2 hours, the reaction mass was cooled down to 5-10 C and acidified with 32% hydrochloric acid to a pH value of 1 .8. After stirring for another hour, the reaction mass was filtered with a suction filter. Then the cake was washed with cold water (8-10 C) and dried under vacuum to yield 6-nitro-anthranilic acid in an amount of 88% of theory.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitrophthalimide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; MURUDI, Vikrant; SHYADLIGERI, Ashok Shankarappa; MISHRA, Brijnandan Premnath; LUGINBUEHL, Markus Adolf; FUERST, Maren; WO2011/98386; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24566-79-8, name is N-(6-Bromohexyl)phthalimide, A new synthetic method of this compound is introduced below., COA of Formula: C14H16BrNO2

To a stirred solution of compound 3-i (6.39 g, 20.3 mol) in DMF (60 mL) was added potassium thioacetate (2.78 g, 34.3 mmol) portion wise and stirred for 20 mm at room temperature. After complete addition, the reaction mixture was stirred at room temperature for 30 mm. Reaction progress was monitored by TLC; after completion the reaction mixture was quenched with ice-cold water (250 mL) and stirred for 1 h. The resultant precipitated was filtered, washed with water (100 mL) and dried in vacuo to afford 4-i as an off-white solid(5.8 g, 93.5%). LCMS: 306.20 (M+1).

The synthetic route of 24566-79-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
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Indoline | C8H9N – PubChem

Related Products of 4702-13-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4702-13-0, name is N-Phthaloylglycine belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Reference Example 4 Phthalimidoacetyl chloride A mixture of phthalimidoacetic acid (25.1 g, 0.122 mol) and thionyl chloride (50 mL) was heated for one hour under reflux. The reaction mixture was cooled and, then, concentrated under reduced pressure. The concentrate was recrystallized from dichloromethane-hexane to give 26.4 g (97%) the titled compound, which was used for the subsequent reaction without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Phthaloylglycine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US5834463; (1998); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 3484-35-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3484-35-3, name is 5-Methylindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 3-substituted-5-benzylidene-2-thioxo-4-thiazolidinone (3a-3h, 8a-8f) (0.003 mol) in 1,4-dioxane (15 ml) was added HC(OEt)3 (2 ml) and BF3¡¤Et2O (2 ml). The reaction mixture was heated to 80 C and stirring was continued at the same temperature for 4 h. The resulting 2-ethylthio-3-substituted-5-benzylidene-4-thiazolium fluoroborate (4a-4h, 9a-9f) was precipitated, filtered off, and dried without any additional purification, as starting material for the following reactions. To a mixture of thiazolium fluoroborate (4a-4h, 9a-9f) (0.003 mol) and indolin-2-one (11a-11f) (0.003 mol) in acetonitrile (15 ml) was added triethylamine (0.91 g, 0.009 mol) dropwise at 25 C, and the mixture was stirred for 4 h at the same temperature. The orange precipitate was collected and washed with ethyl acetate (8 ml). The crude product thus obtained was recrystallized from methanol or acetone to give compound (5a-5s, 10a-10s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methylindolin-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Shuobing; Zhao, Yanfang; Zhang, Guogang; Lv, Yingxiang; Zhang, Ning; Gong, Ping; European Journal of Medicinal Chemistry; vol. 46; 8; (2011); p. 3509 – 3518;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 20870-78-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20870-78-4, name is 5-Bromoindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5-(4,4,5,5-Tetramethyl-l,3,2-dioxaboroIan-2-yl)-l,3-dihydroindol-2-one; A mixture of 5-bromo-2,3-dihydroindol-2-one (500 mg), bis(pinacolato)diboron (899 mg) and potassium acetate (695 mg) in DMF (20 mL) was degassed for 5 minutes. 1,1′- 5 Bis(diphenylphosphino)ferrocenedichloropalladium(II) dichloromethane adduct (78 mg) was added to the mixture and the reaction was heated to 8O0C and left to stir for 3 hours. The reaction mixture was filtered through celite and concentrated in vacuo. The residue was suspended in water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The organics were dried (MgSO4), filtered and concentrated in vacuo to give the desired 0 material as a brown solid. (611 mg). Mass Spectrum; M+H+MeCN+ 301.NMR Spectrum: 1H NMR (DMSOd6) deltal.28 (12H, s), 3.47 (2H, s), 6.82 – 6.84 (IH, d), 7.51 (2H, m), 10.52 (IH, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromoindolin-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/80382; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5332-26-3, Application In Synthesis of 2-(Bromomethyl)isoindoline-1,3-dione

General procedure: The vacuum dried intermediate 3 (0.002 mol) was then reacted with mono- and di-substituted benzoic acids (0.003 mol) separately in presence of anhydrous potassium carbonate (0.003 mol) in DMF (10 mL). The reaction mixture was stirred at room temperature for about 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured into ice-cold water and allowed stir for 10 min. The solid obtained was filtered and washed successively with distilled water and recrystallized from ethanol to obtain4(a-n).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kumar, C.S. Chidan; Loh, Wan-Sin; Chandraju, Siddegowda; Win, Yip-Foo; Tan, Weng Kang; Quah, Ching Kheng; Fun, Hoong-Kun; PLoS ONE; vol. 10; 3; (2015);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

39755-95-8, name is 5-Methoxyisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H7NO3

General procedure: A mixture of malononitrile (1 mmol), isatin (1 mmol), dicarbonyl (1 mmol), PEGOSO3H(0.1 mmol), and water (2 mL) was stirred under reflux for the appropriate time (shown in Tables 3, 4). After completion of the reaction, the reaction mixture was filtered and the residue was washed with ethanol. The crude solid product was recrystallized from EtOH to afforded the pure products in high purity and yield.Assignment of the structures of the products was based on their 1H NMR, 13C NMR,and IR spectra.

The synthetic route of 39755-95-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nasseri; Zakerinasab; Research on Chemical Intermediates; vol. 41; 8; (2015); p. 5261 – 5270;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 3676-85-5,Some common heterocyclic compound, 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 4-aminophthalimide (0.62 mmol), 2,6-dichlorophenylisocyanate (0.62 mmol), and DMF (cat.) in toluene (3 mL) was heated at 105 C for 19 h. The reaction mixture was concentrated and the crudematerial was purified via preparative HPLC to give compound 117 in 1% yield. ?H NMR (400MHz, DMSO-d6) 11.15 (s, 1H), 9.78 (s, 1H), 8.60 (s, 1H), 8.05 (t, J 1.2 Hz, 1H), 7.73 (d, J1.2 Hz, 2H), 7.57 (d, J= 8.1 Hz, 2H), 7.36 (t, J= 8.1 Hz, 1H). ?3C NIVII{ (101 1VIHz, DMSO)169.63, 169.49, 152.71, 146.11, 134.78, 134.62, 133.35, 129.33, 129.00, 125.49, 124.55, 122.71,111.96.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Aminoisoindoline-1,3-dione, its application will become more common.

Reference:
Patent; THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT; THE UNIVERSITY OF BRITISH COLUMBIA; ROBERGE, Michel; BARADARAN-HERAVI, Alireza; BALGI, Aruna D.; ZIMMERMANN, Carla D.; KRAUSE, Alexandra; PFEIFER, Thomas Arthur; JAQUITH, James Brian; TAN, Jason Samuel; SHIDMOOSSAVEE, Fahimeh S.; ARNS, Stephen Paul; BAUDELET, Davy Jeremy; (354 pag.)WO2017/49409; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem