Indolines-derivatives

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114041-16-6 as follows. COA of Formula: C10H13NO2

General procedure: Compound 8 (70.6 mg, 0.24 mmol) and 5,6-dimethoxyisoindoline(68.5 mg, 0.38 mmol) were dissolved in CH3CN (30 mL), followed by addition of K2CO3 (138.8 mg, 1.00 mmol). The mixture was heated under reflux and stirred at 90 C for 6 h. After cooling and filtration, the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate/triethyamine) = 10:10:1, v/v/v) to afford 13(56.8 mg, 59%)

According to the analysis of related databases, 114041-16-6, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 102359-00-2

Example 30 COMPOUND IN-022 2-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-carboxylic acid 2-Oxo-2,3-dihydro-1H-indole-5-carboxylic acid was condensed with 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde to give the title compound. 1H-NMR (360 MHz, DMSO-d6) delta 12.74 (s, 1H, NH), 11.42 (br s, 1H, NH), 8.31 (s, 1H), 8.12 (s, 1H), 7.84 (dd, 1H), 7.53 (d, 1H), 7.2 (3, 1H), 7.14 (m, 1H), 7.0 (m, 2H), 4.26 (m, 2H, CH2), 2.94 (m, 2H, CH2), 2.49 (m, under DMSO), 1.67 (m, 4H, 2*CH2). MS-Ve APCI m/z 416.5 [M+-1].

The synthetic route of 2-Oxoindoline-5-carboxylic Acid has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-40-7, name is 5-Nitroisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 89-40-7

In a 250 ml two-necked flask, 40 ml of absolute ethanol and 10 ml of distilled water, 14.56 g (0.26 mol) of iron powder and 1.643 g (0.031 mol) of ammonium chloride were added.10g (0.052mol) of 4-nitrophthalimide was added under stirring without nitrogen protection; the temperature was set at 65 C, and the reaction was about 4 h.TCL shows that the disappearance of the starting point of the reaction is completed; the pH of the solution is adjusted to 9-10 by sodium carbonate, the filter cake is filtered and dried, and extracted with 100 ml of absolute ethanol (85 C) for 3 times.Ethanol distilled under reduced pressure to give a yellow solid 7.5g, yield 89.03%.

The synthetic route of 89-40-7 has been constantly updated, and we look forward to future research findings.

Reference of 7699-18-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7699-18-5, name is 5-Methoxyindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows.

Example A lOO. (l R*.2S*V5′-methoxy-l’-methyl-2-(3-(4-(4-methylpiperazin-l- vDphenv?-l H-indazol–v?spirofcvclopropane-U’-indolini^’-one Sigma^^-trifluoroacetateA . 5-methoxy- 1 -methylindolin-2-oneA dry round-bottom flask was charged with NaH (60% wt) (64 mg, 1.61 mmol) and toluene (2.0 mL). The suspension was heated to 100 0C and then 5-methoxyindolin-2- one (250 mg, 1.53 mmol) was added. After 30 min at 100 0C, Me2SO4 (0.16 mL, 1.68 mmol) was added and the temperature maintained at 1000C for 2.5 h. The reaction was cooled to room temperature and the solvent was removed in vacuo. The residue was purified by column chromatography (silica gel, hexanes/EtOAc, 3: 1 to 2:1) to give the product as a beige solid (144mg, 53%); MS ESI 164.1 [M + H]+, calcd for [C9H9NO2 +H]+ 164.07.

The chemical industry reduces the impact on the environment during synthesis 5-Methoxyindolin-2-one. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3891-07-4 as follows. name: 2-(2-Hydroxyethyl)isoindoline-1,3-dione

Into the reaction tank, put 350 kg of toluene, stirring temperature, distillation of toluene, after the liquid in the water separator is filled, keep the reflux water for 60 minutes, and take a sample to measure the water, when the water content of the reflux liquid is ?0.2%, the reflux is changed to distillation, distilled 45kg of toluene (worked ethyl 4-chloroacetoacetate as a dilution solvent), stirring and lowering the temperature, when the temperature in the tank drops to 45 C, the reaction tank is filled with nitrogen, continue to cool down at-5 C, under stirring add 40 kg of N-(2-hydroxyethyl)-phthalimide, and the add 20 kg of sodium hydride, after the addition, cover the can lid, stirring at -5 C, into the metering tank draw 38.4 kg of ethyl 4-chloroacetoacetate, 45 kg of toluene and mix well, at -5 C condition added the drops of ethyl 4-chloroacetoacetate toluene solution, the dropping time is controlled at 4 hours, after the addition, the reaction is stirred and the temperature is slowly increased, the temperature of the reaction solution is slowly raised at 32 C within 5 hours, the reaction time is more than 12 hours, and the temperature is raised at 45 C to continue the heat preservation, until the reaction is complete, cool down, control the internal temperature of 25 C, add 61 kg of glacial acetic acid, after the addition, continue stirring to make the material in the reaction solution stir evenly, and the internal temperature is controlled at 25 C, add 180kg of water, add, continue to stir for 30 minutes, stop nitrogen filling, stop stirring, let stand, divide the water layer into the barrel and transfer the toluene layer to the washing tank, transfer the water layer into the reaction tank, into the reaction tank add 75kg of toluene, stir and let stand, the water layer is separated into barrels, and the toluene layer is transferred to a washing tank, the water layer is transferred into the reaction tank, 75 kg of toluene is added into the reaction tank, stirred, and allowed to stand, and the water layer was separated, combine the toluene layer into a water wash tank, add 100kg of 25% salt water to the washing tank, stir for 15 minutes, let stand for 30 minutes, and separate the water layer, obtained 4-[(2-phthalimido) ethyoxyl] ethyl acetoacetate toluene solution

According to the analysis of related databases, 3891-07-4, the application of this compound in the production field has become more and more popular.

Electric Literature of 675109-26-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 675109-26-9 name is 6-Bromoisoindolin-1-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 265: (S)-3-Oxo-N-((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)- pyridin-2-yl)methyl)isoindoline-5-carboxamide To a 25 mL round bottom flask containing (S)-(4-(trifluoromethyl)- phenyl)(3 -(trifiuoromethyl)pyridin-2-yl)methanamine hydrochloride (Intermediate 1) (120 mg, 0.336 mmol) was added toluene (3 mL). The resulting mixture was stirred at rt for 2 min. At this time,sodium carbonate (143 mg, 1.346 mmol), 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (3.89 mg, 6.73 muiotaetaomicron), palladium (II) acetate (1.5 mg, 6.7 muiotaetaomicron) and 6-bromo-2,3-dihydro-isoindol-l-one (71.3 mg, 0.336 mmol) were added to the flask. The reaction vessel was flushed with argon and then left under 1.0 atm of carbon monoxide gas (from a lecture bottle, in hood). The flask was heated to 85 C overnight, filtered though Celite brnad filter agent, and eluted with EtOAc. Purification by reverse phase HPLC, and concentration of the containing fractions gave (S)-3-oxo-N-((4-(trifiuoromethyl)- phenyl)(3-(trifiuoromethyl)pyridin-2-yl)methyl)isoindoline-5-carboxamide as a yellow foamy solid. 1H NMR (300MHz , CDC13): delta ppm 8.92 (d, J = 4.5 Hz, 1H), 8.40 (d, J = 7.7 Hz, 1 H), 7.60 – 7.56 (m, 5 H), 7.46 – 7.48 (m, 2 H), 6.90 (d, J = 7.6 Hz, 1 H), 4.54 (s, 2 H). MS 480.1 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromoisoindolin-1-one, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 550-44-7, name is 2-Methylisoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Methylisoindoline-1,3-dione

ZrCl4 (8.7 g, 37.3 mmol) was added slowly to a solution of 2-methylisoindoline-1,3- dione (41.1, 3.0 g, 18.6 mmol) in THF (50 mL) at -20 C. The mixture was stirred at -20 C for 1h. MeMgBr (1 M, 111.6 mL, 111.6 mmol) was added slowly to the reaction at -20 C. The mixture was stirred at room temperature overnight. The reaction mixture was poured into 5N NaOH solution (while keeping pH 14) and extracted with DCM. The organic solution was concentrated to afford 1,1,2,3,3-pentamethylisoindoline (41.2) as a brown oil (1.0 g, 28%).

According to the analysis of related databases, 550-44-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 16800-68-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16800-68-3, name is 1-Acetylindolin-3-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 1a (35 mg, 0.2 mmol) and 2a (52.4 mg,0.4 mmol) in DCE (3 mL) was added iodine (10 mg, 0.04 mmol). The reaction mixture was heated at 80 C for 24 h, then cooled to room temperature and quenched with saturated sodium thiosulfate. The mixture was extracted with CH2Cl2, the combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel to afford title compound.

The synthetic route of 1-Acetylindolin-3-one has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106352-01-6, name is 3-((1,3-Dioxoisoindolin-2-yl)methyl)benzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-((1,3-Dioxoisoindolin-2-yl)methyl)benzoic acid

To 3-(1 ,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoic acid (300 mg, 1.066 mmol) in DCM (1 mL9 are added at O0C triethylamine (164 uL, 1.173 mmol) and ethylchloroformate (112 uL, 1.173 mmol). After stirring at O0C during 15 min and filtration, the obtained solution is added at 0C to NaBH4 (61 mg, 1.599 mmol) in water (400 uL) before stirring at 00C during 30 min and at rt during 2h. The solution is acidified to pH 3 with an aqueous 1N HCI solution, extracted with ethylacetate, the organic phase is dried and evaporated to give a crude compound before purification by flash chromatography on silica gel (eluent: cyclohexane/ethyl acetate 9/1 to 1/1) to yield a colorless gum. TLC, Rf (cyclohexane/ethyl acetate 1/1) = 0.15.

The synthetic route of 106352-01-6 has been constantly updated, and we look forward to future research findings.

Related Products of 120266-80-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120266-80-0, name is 5-Aminoindolin-2-one hydrochloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5-lsothiocyanato-1 ,3-dihydro-indol-2-oneTo a stirring solution of 5-amino- ,3-dihydro-indol-2-one hydrochloride (2 g, 10.83 mmol) and diisopropylethylamine (4.19 g, 32.49 mmol) in drydichloromethane (100 ml) at 0 C under N2, thiophosgene (1.49 g, 10.83 mmol) in dichloromethane is added dropwise and stirred for 30 minutes. The reaction mixture is quenched with water (100 ml) and the layers are separated, the organic layer is washed with water (50 ml X2) and dried over anhydrous MgS04 to get the product as brown crystalline solid (2.03 g, 99.02 %); TLC: chloroform/methanol (9.5/0.5) Rf- 0.5;1H-NMR (400 MHz, DMSO-d6): delta [ppm] 10.60 (s, 1H), 7.31 (s, 1 H), 7.25 (d, J = 7.88 Hz, 1H), 6.82 (d, J = 8.24 Hz, 1 H), 3.50 (s, 2H

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Aminoindolin-2-one hydrochloride, other downstream synthetic routes, hurry up and to see.