Indolines-derivatives

Reference of 3485-84-5, These common heterocyclic compound, 3485-84-5, name is N-Vinylphthalimide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a reactor, 2 g of the compound obtained in Step A, 2 eq. of N-vinylphthalimide, 1.25 eq. of diisopropylethylamine and 0.05 eq. of palladium tetrakis(triphenylphosphine) are introduced into toluene and heated at reflux. The reaction is continued at reflux for 12 hours and then the reaction mixture is cooled to ambient temperature. Ethyl acetate is added, and then washings with water and IN HCl solution are carried out. After evaporating off the solvents, the residue obtained is purified by chromatography on silica gel (eluant:dichloromethane/heptane 1/1, and then dichloromethane) to yield the title product in a yield of 80% and with a chemical purity of more than 95%.Melting point: 146 C.

The synthetic route of 3485-84-5 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 320734-35-8, name is 7-Bromooxindole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 7-Bromooxindole

To a solution of 7-bromo-l,3-dihydro-2H-indol-2-one (200 mg, 0.94 mmol) in DMF (5 mL) were added cesium carbonate (676 mg, 2.07 mmol) and iodomethane (294 mg, 2.07 mmol). The reaction mixture was stirred at ambient temperature for 18 h, then partitioned between H2O (50 mL) and EtOAc (100 mL). The organic extract was dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with a gradient of hexane: EtOAc – 100:0 to 85:15, to give the title compound. MS: mlz = 254 (M + 1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 320734-35-8.

Adding a certain compound to certain chemical reactions, such as: 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 446292-08-6, Product Details of 446292-08-6

Put the compound of formula II (42.1g), ethanol (252mL), and n-butylamine (47.2g, 8eq) into the reaction flask, warm the temperature to 75-80 C, and hold the reaction for 8-12 hours. After the reaction is completed, cool the reaction solution to 0 to 5 C, heat and stir for 1 hour, filter the obtained solid,The filter cake was rinsed with ethanol (20 mL) and dried to obtain the intermediate compound of formula I (23.3 g), purity (HPLC) 99.57%, and yield 80%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39603-24-2, Computed Properties of C10H9NO2

General procedure: A solution of an isatin (3) (1 mmol), a C-H acidderivative (2) (1 mmol), and naphthalen-1-amine (1)(1 mmol) was heated at 80 C in acetic acid (5 mL)for 24 h. After completion of the reaction as indicatedby TLC (MeOH/AcOEt, 1:4), the residue wasfiltered and washed successively with gl. acetic acid andCHCl3 (3 × 10 ml). The crude product thus obtainedwas crystallized from MeOH or EtOH and dried atroom temperature. The final product was obtained as a powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dimethylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference of 611-09-6, A common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a well-stirred solution of isatin and malononitrile(1 mmol each) in ethanol (95%, 4 mL) was added dimedone,4-hydroxycoumarin, 4-hydroxy-N-methylquinolin-2-one,or 2-methyl-pyrazol-2-one [generated in situ from ethylacetoacetate and hydrazine hydrate, 1 mmol each]. To thissolution was added THAM (30 mol %) and stirring wascontinued at ambient temperature. Upon completion of thereaction (TLC), water (5 mL) was added and stirring wascontinued for 10 min more. Resultant solid product wasfiltered, washed repeatedly with water, and dried. The dried solid was washed thrice with hexaneechloroformmixture (1:1, v/v) and dried again. Resultant product didnot require any further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-(Trifluoromethoxy)indoline-2,3-dione

Information Example 2: 5-Trifluoromethoxy-1H-indole Lithium aluminum hydride (10.4 mL,1M in THF, 10.4 mmol) was added to a solution of 5-trifluoromethoxyistatin (0.8 g, 3.45 mmol) in THF at room temperature and the mixture was refluxed overnight. The reaction mixture was cooled, and Na2SO4·10H2O was added very carefully portionwise, followed by ethyl acetate. The reaction mixture was then filtered, and the filtrate was evaporated. The residual oil was purifed by column chromatography with ethyl acetate in hexanes (2:98) to yield 5-trifluoromethoxy-1H-indole (0.162 g, 23%).

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6326-79-0, name is 6-Bromoisatin, A new synthetic method of this compound is introduced below., Product Details of 6326-79-0

To a round bottom flask containing 6-bromoindoline-2,3-dione (1 g, 4.42 mrnol) was added NaOH (4.9 mL, 4.87 mmol) and stirred at 50 C for I h. The reaction mixture is then brought to ii and cooled to 0C before adding a solution of NaNO2 (0.31 g, 4.42 mmol) in 1-120 (1 1 mL) dropwise over a period of 15 mins, The above mixture was then added to a solution of H20 (9 mL) and H2S04 (46 mL) thai is precooled to 0 C dropwise over a period of 15 mins. The crude mixture was then added to a mix of cone. HCI (4 mL)and SnC1?.2H20 (2.5 g, 11.06 rnmoi) at ii and continued to stir at rt for I h. The solids are then filtered and dried to give the crude product 6-hromo-IH-indazoie-3-carhoxyiic acid (Intermediate I 12A) (1.1 g, 93%) as a tan solid. The crude product was taken to the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 111992-61-1, name is 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111992-61-1, Formula: C13H14BrNO2

Step 3A suspension of 3-(4-phenoxyphenyl)-l H-pyrazolo[3,4-d]pyrimidin-4-amine (400 mg, 1.3 mmol, 1.00 equiv), 2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro- lH-isoindole-l ,3- dione (570 mg, 1.95 mmol, 1.50 equiv) and cesium carbonate (847 mg, 2.60 mmol, 2.00 equiv) in NMP (50 mL) was stirred at 100C for 12 h under nitrogen atmosphere. It was quenched with water (150 mL). The resulting solution was extracted with ethyl acetate (5 x 30 mL). The organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column eluting with dichloromethane / methanol (10 / 1 ). This resulted in 280 mg (41 %) of 2-(2-[[4-amino-3-(4-phenoxyphenyl)- lH-pyrazolo[3,4-d]pyrimidin-l -yl]memyl]-2-memylpropyl)-2,3-dihydro-I H-isoindole-l ,3- dione as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Reference of 87-48-9, These common heterocyclic compound, 87-48-9, name is 5-Bromoindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of isatin (6a-e, 1.0 g) and hydrazine-hydrate (5 mL,~30 mmol) in ethylene glycol, potassium hydroxide (10 equiv.) was added and the resulting reaction mixturewas stirred at 110-130 C for 2-3 h (reaction monitored by TLC). The reaction mixture wascooled to room temperature, poured into ice-cold water (50 mL), acidified to pH 2 with 6N hydrochloric acid and extracted with ethylacetate (3 30 mL). The organic extracts were combined, washed with brine (15 mL), dried over sodium sulfate and concentrated in vacuo. The obtained residue was purified by column chromatography using ethyl acetate-hexane as eluents to furnish 7a-e in moderate yields.

Statistics shows that 5-Bromoindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 87-48-9.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., name: 5-Aminoisoindoline-1,3-dione

Potassiumhydroxide (0.35 g,6.17 mmol) was added to a solution of 4-aminophthalimide 10 (1.00 g, 6.17 mmol) in dimethylformamide(30 mL) and the mixture was stirred at ambient temperature for 2 h. Iodomethane (0.88 g, 6.17 mmol) wasadded and it was stirred for another 18 h at the same temperature. Water (50 mL) and ethyl acetate (50 mL)was added and the resulting phases were separated. The organic phase was washed with brine, driedover sodium sulfate and concentrated in vacuum. Purification by chromatography on silica gel (Gradient:0-100% ethyl acetate in cyclohexane) afforded the title compound 11a as a yellow solid (1.00 g, 92% yield):1H-NMR (DMSO-d6): delta = 7.46 (d, J = 8.24 Hz, 1H), 6.90 (d, J = 2.00 Hz, 1H), 6.77 (dd, J = 8.24 Hz, 2.00 Hz,1H), 6.42 (br. s, 2H), 2.94 (s, 3H) ppm. 13C-NMR (DMSO-d6): delta = 168.87, 168.57, 155.27, 135.10, 125.17,117.33, 116.84, 107.42, 23.83 ppm. MS (m/z): 177 [M+ H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.