Tag: M.W=100-150

Product Details of 59-48-3. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

Product Details of 59-48-3. Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions WOS:000480500600023 published article about PLASMODIUM-FALCIPARUM M1; ACUTE NONLYMPHOCYTIC LEUKEMIA; MOLECULAR-DYNAMICS; CLINICAL-SIGNIFICANCE; EFFICIENT GENERATION; STRUCTURAL BASIS; AM1-BCC MODEL; CD13; BESTATIN; CANCER in [Lee, Jisook; Vinh, Natalie B.; Schembri, Luke S.; Gazdik, Michelle; Scammells, Peter J.] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville Campus, Parkville, Vic 3052, Australia; [Charman, Susan A.] Monash Univ, Monash Inst Pharmaceut Sci, Ctr Drug Candidate Optimisat, Parkville Campus, Parkville, Vic 3052, Australia; [Drinkwater, Nyssa; Yang, Wei; Sivaraman, Komagal Kannan; McGowan, Sheena] Monash Univ, Infect & Immun Program, Biomed Discovery Inst, Clayton Campus, Clayton, Vic 3800, Australia; [Drinkwater, Nyssa; Yang, Wei; Sivaraman, Komagal Kannan; McGowan, Sheena] Monash Univ, Dept Microbiol, Clayton Campus, Clayton, Vic 3800, Australia; [Grin, Peter M.; Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada; [Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Dept Oral Biol & Med Sci, Vancouver, BC V6T 1Z3, Canada; [Grin, Peter M.; Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Ctr Blood Res, Vancouver, BC V6T 1Z3, Canada in 2019, Cited 80. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Formula: C8H7NO

Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inhibitors of the APN homologue from the malarial parasite Plasmodium falciparum M1 aminopeptidase (PfA-M1). Herein, we describe the rationale that underpins the repurposing of PfA-MI inhibitors as novel APN inhibitors. A series of novel hydroxamic acid analogues were developed using a structure-based design approach and evaluated their inhibition activities against APN. N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yOethyl)-4(methylsulfonamido)benzamide (6ad) proved to be an extremely potent inhibitor of APN activity in vitro, selective against other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxicity against Ad293 cells and favorable physicochemical and metabolic stability properties. The combined results indicate that compound 6ad may be a useful lead for the development of anticancer agents.

Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.. Formula: C8H7NO

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors published in 2020. SDS of cas: 59-48-3, Reprint Addresses Hay, DL (corresponding author), Univ Auckland, Sch Biol Sci, Auckland 1010, New Zealand.; Flanagan, JU; Hay, MP; Hay, DL (corresponding author), Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1010, New Zealand.; Flanagan, JU; Hay, MP (corresponding author), Univ Auckland, Auckland Canc Soc Res Ctr, Auckland 1023, New Zealand.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

Class B G protein-coupled receptors are highly therapeutically relevant but challenges remain in identifying suitable small-molecule drugs. The calcitonin-like receptor (CLR) in particular is linked to conditions such as migraine, cardiovascular disease, and inflammatory bowel disease. The CLR cannot act as a cell-surface receptor alone but rather must couple to one of three receptor activity-modifying proteins (RAMPs), forming heterodimeric receptors for the peptides adrenomedullin and calcitonin gene-related peptide. These peptides have extended binding sites across their receptors. This is one reason why there are few small-molecule ligands that can modulate these receptors. Here we describe small molecules that are able to positively modulate the signaling of the CLR with all three RAMPs but are not active at the related calcitonin receptor. These compounds were selected from a beta-arrestin recruitment screen, coupled with rounds of medicinal chemistry to improve their activity. Translational potential is shown as the compounds can positively modulate cAMP signaling in a vascular cell line model. Binding experiments do not support an extracellular domain binding site; however, molecular modeling reveals potential allosteric binding sites in multiple receptor regions. These are the first small-molecule positive modulators described for the CLR:RAMP complexes.

SDS of cas: 59-48-3. Welcome to talk about 59-48-3, If you have any questions, you can contact Hendrikse, ER; Liew, LP; Bower, RL; Bonnet, M; Jamaluddin, MA; Prodan, N; Richards, KD; Walker, CS; Pairaudeau, G; Smith, DM; Rujan, RM; Sudra, R; Reynolds, CA; Booe, JM; Pioszak, AA; Flanagan, JU; Hay, MP; Hay, DL or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

In 2020.0 J MED CHEM published article about SPHINGOLIPID METABOLISM; CELLULAR-RESPONSES; GAUCHER-DISEASE; SPHINGOSINE-1-PHOSPHATE; POTENT; GLUCOSYLSPHINGOSINE; GLUCOSYLCERAMIDE; ACCUMULATION; PURIFICATION; DEFICIENCY in [Lansbury, Peter; Liu, Min; Skerlj, Renato] Lysosomal Therapeut Inc, Cambridge, MA 02139 USA; [Di Martino, Simona; Tardia, Piero; Cilibrasi, Vincenzo; Caputo, Samantha; Mazzonna, Marco; Realini, Natalia; Margaroli, Natasha; Migliore, Marco; Pizzirani, Daniela; Scarpelli, Rita] Fdn Ist Italiano Tecnol, Drug Discovery & Dev D3 Validat, I-16163 Genoa, Italy; [Russo, Debora; Penna, Ilaria] Fdn Ist Italiano Tecnol, D3 Pharma Chem, I-16163 Genoa, Italy; [Ottonello, Giuliana; Bertozzi, Sine Mandrup; Armirotti, Andrea] Fdn Ist Italiano Tecnol, Analyt Chem Lab, I-16163 Genoa, Italy; [Duc Nguyen; Bongarzone, Ernesto R.] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Myelin Regenerat Grp, Chicago, IL 60612 USA; [Sun, Ying] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Dept Pediat,Div Human Genet, Cincinnati, OH 45229 USA in 2020.0, Cited 58.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. COA of Formula: C8H7NO

Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important members of the SphL family. Herein, we describe the lead optimization studies of benzoxazolone carboxamides resulting in piperidine 22m, where we demonstrated target engagement in two animal models of neuropathic lysosomal storage diseases (LSDs), Gaucher’s and Krabbe’s diseases. After daily intraperitoneal administration at 90 mg kg(-1), 22m significantly reduced the brain levels of the toxic lipids glucosylsphingosine (GluSph) in 4L;C* mice and galactosylsphingosine (GalSph) in Twitcher mice. We believe that 22m is a lead molecule that can be further developed for the correction of severe neurological LSDs where GluSph or GalSph play a significant role in disease pathogenesis.

COA of Formula: C8H7NO. Welcome to talk about 59-48-3, If you have any questions, you can contact Di Martino, S; Tardia, P; Cilibrasi, V; Caputo, S; Mazzonna, M; Russo, D; Penna, I; Realini, N; Margaroli, N; Migliore, M; Pizzirani, D; Ottonello, G; Bertozzi, SM; Armirotti, A; Nguyen, D; Sun, Y; Bongarzone, ER; Lansbury, P; Liu, M; Skerlj, R; Scarpelli, R or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Recently I am researching about TERT-BUTYL HYDROPEROXIDE; SELECTIVE OXIDATION; MANGANESE-DIOXIDE; AEROBIC OXIDATION; SATURATED-HYDROCARBONS; CARBONYL-COMPOUNDS; ALKYLARENES; ALKANES; BONDS; MILD, Saw an article supported by the Council of Scientific and Industrial Research, IndiaCouncil of Scientific & Industrial Research (CSIR) – India [02(0296/17/EMR-II)]; SERB-NPDF [PDF/2017/001286]; CSIRCouncil of Scientific & Industrial Research (CSIR) – India; IISER-Pune. Quality Control of Indolin-2-one. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Pandey, AM; Agalave, SG; Vinod, CP; Gnanaprakasam, B. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

Herein, we report a highly chemoselective and efficient heterogeneous MnO2@Fe3O4 MNP catalyst for the oxidation of benzylic sp(3) C-H group of ethers using TBHP as a green oxidant to afford ester derivatives in high yield under batch/continuous flow module. This catalyst was also effective for the benzylic sp(3) C-H group of methylene derivatives to furnish the ketone in high yield which can be easily integrated into continuous flow condition for scale up. The catalyst is fully characterized by spectroscopic techniques and it was found that 0.424 % MnO2@Fe3O4 catalyzes the reaction; the magnetic nanoparticles of this catalyst could be easily recovered from the reaction mixture. The recovered catalyst was recycled for twelve cycles without any loss of the catalytic activity. The advantages of MnO2@Fe3O4 MNP are its catalytic activity, easy preparation, recovery, and recyclability, gram scale synthesis with a TOF of up to 14.93 h(-1) and low metal leaching during the reaction.

Welcome to talk about 59-48-3, If you have any questions, you can contact Pandey, AM; Agalave, SG; Vinod, CP; Gnanaprakasam, B or send Email.. Quality Control of Indolin-2-one

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Product Details of 59-48-3. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

Welcome to talk about 59-48-3, If you have any questions, you can contact Vaidya, GN; Nagpure, M; Kumar, D or send Email.. Product Details of 59-48-3

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article MnO2@Fe3O4 Magnetic Nanoparticles as Efficient and Recyclable Heterogeneous Catalyst for Benzylic sp(3) C-H Oxidation WOS:000486976800001 published article about TERT-BUTYL HYDROPEROXIDE; SELECTIVE OXIDATION; MANGANESE-DIOXIDE; AEROBIC OXIDATION; SATURATED-HYDROCARBONS; CARBONYL-COMPOUNDS; ALKYLARENES; ALKANES; BONDS; MILD in [Pandey, Akanksha M.; Agalave, Sandip G.; Gnanaprakasam, Boopathy] Indian Inst Sci Educ & Res, Dept Chem, Pune 411008, Maharashtra, India; [Vinod, Chathakudath P.] CSIR NCL Catalysis & Inorgan Chem Div, Pune, Maharashtra, India in 2019, Cited 75. SDS of cas: 59-48-3. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

Herein, we report a highly chemoselective and efficient heterogeneous MnO2@Fe3O4 MNP catalyst for the oxidation of benzylic sp(3) C-H group of ethers using TBHP as a green oxidant to afford ester derivatives in high yield under batch/continuous flow module. This catalyst was also effective for the benzylic sp(3) C-H group of methylene derivatives to furnish the ketone in high yield which can be easily integrated into continuous flow condition for scale up. The catalyst is fully characterized by spectroscopic techniques and it was found that 0.424 % MnO2@Fe3O4 catalyzes the reaction; the magnetic nanoparticles of this catalyst could be easily recovered from the reaction mixture. The recovered catalyst was recycled for twelve cycles without any loss of the catalytic activity. The advantages of MnO2@Fe3O4 MNP are its catalytic activity, easy preparation, recovery, and recyclability, gram scale synthesis with a TOF of up to 14.93 h(-1) and low metal leaching during the reaction.

SDS of cas: 59-48-3. Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

I found the field of Chemistry very interesting. Saw the article One-Pot Regiodirected Annulations for the Rapid Synthesis of pi-Extended Oligomers published in 2020.0. Application In Synthesis of Indolin-2-one, Reprint Addresses Pasini, D (corresponding author), Univ Pavia, Dept Chem, I-27100 Pavia, Italy.; Pasini, D (corresponding author), Univ Pavia, INSTM Res Unit, I-27100 Pavia, Italy.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

We demonstrate the broad applicability of the annulation protocol combining, in one pot, a direct arylation and cross aldol condensation for the straightforward synthesis at gram-scale of pi-extended thiophene-based scaffolds. The regiospecific direct arylation drives the subsequent cross-aldol condensation proceed under the same basic conditions, and the overall protocol has broad applicability in the synthesis of extended aromatics wherein the thiophene ring is annulated with furans, pyridines, indoles, benzothiophenes, and benzofurans. These scaffolds can be further elaborated into pi-extended, highly fluorescent oligomers with a central deficient benzothiadiazole unit with up to nine aromatic rings through coupling reactions.

Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of Indolin-2-one

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article One-Pot Regiodirected Annulations for the Rapid Synthesis of pi-Extended Oligomers WOS:000526894000079 published article about DIRECT ARYLATION; BITHIOPHENE COPOLYMERS; CONJUGATED POLYMER; HIGH-PERFORMANCE; MATERIALS DESIGN; CONVERSION in [Nitti, Andrea; Osw, Peshawa; Calcagno, Giuseppe; Pasini, Dario] Univ Pavia, Dept Chem, I-27100 Pavia, Italy; [Nitti, Andrea; Pasini, Dario] Univ Pavia, INSTM Res Unit, I-27100 Pavia, Italy; [Osw, Peshawa] Salahaddin Univ, Coll Sci, Dept Chem, Erbil 44001, Kurdistan, Iraq; [Botta, Chiara] CNR, Ist Studio Macromol ISMAC, I-20133 Milan, Italy; [Etkind, Samuel I.; Swager, Timothy M.] MIT, Dept Chem, Cambridge, MA 02139 USA; [Bianchi, Gabriele; Po, Riccardo] Ist Donegani SpA, Res Ctr Renewable Energies & Environm, I-28100 Novara, Italy in 2020.0, Cited 43.0. Product Details of 59-48-3. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

We demonstrate the broad applicability of the annulation protocol combining, in one pot, a direct arylation and cross aldol condensation for the straightforward synthesis at gram-scale of pi-extended thiophene-based scaffolds. The regiospecific direct arylation drives the subsequent cross-aldol condensation proceed under the same basic conditions, and the overall protocol has broad applicability in the synthesis of extended aromatics wherein the thiophene ring is annulated with furans, pyridines, indoles, benzothiophenes, and benzofurans. These scaffolds can be further elaborated into pi-extended, highly fluorescent oligomers with a central deficient benzothiadiazole unit with up to nine aromatic rings through coupling reactions.

Product Details of 59-48-3. Welcome to talk about 59-48-3, If you have any questions, you can contact Nitti, A; Osw, P; Calcagno, G; Botta, C; Etkind, SI; Bianchi, G; Po, R; Swager, TM; Pasini, D or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments WOS:000526392200048 published article about AGOUTI-RELATED PROTEIN; STRUCTURAL BASIS; CYCLIC-PEPTIDES; DISCOVERY; DESIGN; POTENT; TARGETS; SPSB2; RECOGNITION; CYCLIZATION in [Gueret, Stephanie M.] Max Planck Inst Mol Physiol, AstraZeneca, Dept Chem Biol, Max Planck Inst Satellite Unit, D-44227 Dortmund, Germany; [Gueret, Stephanie M.; Plowright, Alleyn T.; Valeur, Eric; Lemurell, Malin] AstraZeneca, Med Chem Res & Early Dev Cardiovasc Renal & Metab, BioPharmaceut R&D, S-43150 Gothenburg, Sweden; [Thavam, Sasikala; Potowski, Marco; Waldmann, Herbert] Max Planck Inst Mol Physiol, Dept Chem Biol, D-44227 Dortmund, Germany; [Carbajo, Rodrigo J.] AstraZeneca, Chem Oncol R&D, Cambridge CB2 0SL, England; [Potowski, Marco; Waldmann, Herbert] TU Dortmund Univ, Fac Chem & Chem Biol, D-44227 Dortmund, Germany; [Larsson, Niklas] AstraZeneca, Discovery Biol, BioPharmaceut R&D, Discovery Sci, S-43150 Gothenburg, Sweden; [Dahl, Goran] AstraZeneca, Struct Biophys & Fragment Based Lead Generat, Discovery Sci, BioPharmaceut R&D, S-43150 Gothenburg, Sweden; [Dellsen, Anita] AstraZeneca, BioPharmaceut R&D, Discovery Sci, Mechanist Biol & Profiling, S-43150 Gothenburg, Sweden; [Grossmann, Tom N.] Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, NL-1081 HV Amsterdam, Netherlands in 2020.0, Cited 69.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. SDS of cas: 59-48-3

Hot loop protein segments have variable structure and conformation and contribute crucially to protein-protein interactions. We describe a new hot loop mimicking modality, termed PepNats, in which natural product (NP)-inspired structures are incorporated as conformation-determining and-restricting structural elements into macrocyclic hot loop-derived peptides. Macrocyclic PepNats representing hot loops of inducible nitric oxide synthase (iNOS) and human agouti-related protein (AGRP) were synthesized on solid support employing macro-cyclization by imine formation and subsequent stereoselective 1,3-dipolar cycloaddition as key steps. PepNats derived from the iNOS DINNN hot loop and the AGRP RFF hot spot sequence yielded novel and potent ligands of the SPRY domain-containing SOCS box protein 2 (SPSB2) that binds to iNOS, and selective ligands for AGRP-binding melanocortin (MC) receptors. NP-inspired fragment absolute configuration determines the conformation of the peptide part responsible for binding. These results demonstrate that combination of NP-inspired scaffolds with peptidic epitopes enables identification of novel hot loop mimics with conformationally constrained and biologically relevant structure.

SDS of cas: 59-48-3. Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem