Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19727-83-4, name is 6-Nitroindoline, A new synthetic method of this compound is introduced below., Product Details of 19727-83-4

The tert-butyl 6-aminoindoline-l-carboxylate used as a starting material was prepared as follows :-Di-tert-butyl dicarbonate (7.2 g) was added to a mixture of 6-nitroindoline (4.92 g) and methylene chloride (50 ml) and the mixture was stirred at ambient temperature for 1 hour. 4-Dimethylaminopyridine (0.37 g) was added and the reaction mixture was stirred at ambient temperature for 16 hours. The resultant mixture was evaporated and the residue was purified by column chromatography on silica using increasingly polar mixtures of petroleum ether (b.p. 40-60C) and ethyl acetate as eluent. There was thus obtained tert-butyl 6-nitroindoline- 1-carboxylate as a solid (5.45 g); 1H NMR: (CDCl3) 1.6 (s, 9H), 3.2 (t, 2H), 4.1 (t, 2H), 7.2 (d, IH), 7.85 (d, IH), 8.3 (br s, 0.5H), 8.7 (br s, 0.5H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/99317; (2007); A1;,
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Related Products of 7477-63-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7477-63-6, name is 7-Chloroisatin, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Isatins (1a?j, 3.0 g), hydrazine hydrate (80percent, 13 mL) and water (13 mL) were added to a flask equipped with a thermometer with vigorous stirring. The reaction mixture was kept at 140 °C in an oil bath for 6 h before being cooled to r.t., when hydrochloric acid (2.0 mol L?1) was added to bring the pH to pH 2. The reaction mixture was stirred at r.t. for 12 h. Compounds 2a?j were obtained by filtering under vacuum and recrystallisation from absolute ethanol.

The chemical industry reduces the impact on the environment during synthesis 7-Chloroisatin. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhang, Chao; Xu, Juan; Zhao, Xinyu; Kang, Congmin; Journal of Chemical Research; vol. 41; 9; (2017); p. 537 – 540;,
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Synthetic Route of 39603-24-2, A common heterocyclic compound, 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To asolution of isatin 3 (1.0mmol), 2-aminopyridine 2 (1.35mmol)andisocyanide 4 (1.35mmol) in 4mL of n-butyl alcohol was added HClO4 (1.0mmol), and the reaction mixture was stirred under refluxfor 8 h. After cooling to room temperature, the precipitate was collected by filtration, rinsed with ethanol and dried to afford the target compound 1.

The synthetic route of 39603-24-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Bo; Tao, Chuanye; Shao, Taofeng; Gong, Jianxian; Che, Chao; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1487 – 1492;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 150544-04-0, name is 6-Aminoindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 150544-04-0

To 6-aminoindolin-2-one (30 mg, 0.202 mmol) in THF (1 mL) was added acetic anhydride (19 uL, 0.202 mmol). After 2 hrs the product was precipitated with ether, filtered and dried to give 25 mg, 66percent of a white solid. 1H NMR (400 MHz, CD3OD) delta 7.41 (s, IH), 7.16 (d, J = 7.0 Hz, IH), 7.00 (d, J = 8.0 Hz, IH), 3.49 (s, 2H), 2.12 (s, 3H); MS ESI 191.0 [M + H]+, calcd for [C10H10N2O2 + H]+ 191.08.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 150544-04-0.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; WO2009/79767; (2009); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112656-95-8, name is 7-Nitroindoline-2,3-dione, A new synthetic method of this compound is introduced below., name: 7-Nitroindoline-2,3-dione

The solution of 7-nitroisatin (15) (1 g, 0.005 mol), malonic acid (0.54 g, 0.005 mol) and piperidine (0.10 ml) in pyridine (10 ml) was refluxed for 50 hours. After cooling to room temperature, the precipitate was collected by vacuum filtration, washed with small amount of solution of hydrochloric acid in 1,4-dioxane (16%) and water, dried on air to give 0.38 g (31 % yield) of (7-nitro-2-oxindole-3-yliden)acetic acid. mp (exp.) = 220-225 0C. Spectrum NMR 1 (DMSO-d6, delta, ppm, J, Hz): 7.06 (s, 1H), 7.45 (t, J = 7.96, 1H), 8.44 (d, J = 7.96, 1H), 8.56 (d, J = 7.83, 1H), 11.32 (s, 1H). Spectrum NMR 13C (DMSO-d6, delta, ppm): 99.98; 118.43; 122.32; 124.37; 128.48; 128.83; 134.26; 141.89; 166.54. IR spectrum (sm-1): 1306; 1348; 1379 (C=C-H), 1531; 1593 (NO2), 1633 (C=O), 1709 (C=O), 3075 (C=O), 3280 (C=O). MS (EI, 70 eV), m/z (I, %): 234 (100, M+), 204 (29), 176 (7), 160 (7), 142 (10), 114 (22), 104 (15), 88 (10), 63 (9), 45 (20), 30 (29).

The synthetic route of 112656-95-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zaryanova, Ekaterina V.; Lozinskaya, Nataly A.; Beznos, Olga V.; Volkova, Maria S.; Chesnokova, Nataly B.; Zefirov, Nikolay S.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 16; (2017); p. 3787 – 3793;,
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Adding a certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8, COA of Formula: C8H9N

1-(1,3-Dihydro-isoindol-2-yl)-ethanoneTo a mixture of 2,3-Dihydro-1 H-isoindole (5.0 g, 41 mmol) and triethylamine (8.5 g, 84 mmol) in dichloromethane (DCM, 200 mL) was added acetyl chloride (3.62 g, 46.16 mmol) dropwise at 0 0C. The resulting mixture was stirred at room temperature overnight, then quenched with 1 N HCI and extracted with dichloromethane. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated to afford 1-(1 ,3-Dihydro-isoindol-2-yl)-ethanone (0.18 g, 85%). MS (ES) m/z: [M+1]: 161.95 (161.08). 1H NMR (400 MHz, CDCI3) 7.31-7.26 (m, 4 H), 4.82 (s, 2 H), 4.80 (s, 2 H), 2.18 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/20306; (2008); A2;,
Indoline – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2307-00-8, name is 5-Amino-2-methylisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., category: indolines-derivatives

4-N-Ethylamino-N-methylphthalimide (5) A mixture of 10 g (0.057 mol) of 4-amino-N-methylphthalimide (4) [Flitsch, Chem. Ber. 94:2494(1961)], 17.5 g (0.11 mol) of diethyl sulfate, and 100 ml of 2,2,2-trifluoroethanol was refluxed for one day. The reaction mixture was cooled, concentrated under reduced pressure, and the residue partitioned between 250 ml of ethyl acetate and 100 ml of saturated sodium bicarbonate solution containing 10 ml of triethylamine. The ethyl acetate phase was separated, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and evaporated. The residue was recrystallized twice from acetone-hexane and then from aqueous methanol to give 3.4 g (29% yield) of the phthalimide (5) as fine yellow crystals, m.p. 157 C. Analysis: Calculated for C11 H12 N2 O2: C, 64.69; H, 5.92; N, 13.71. Found: C, 64.00; H, 5.71; N, 13.37. NMR Spectrum (C5 D5 N): delta 0.5 (t, J=7 Hz, 3H), 2.1 (s, 3H).

The synthetic route of 2307-00-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Miles Laboratories, Inc.; US4261893; (1981); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-74-4, name is 1-Methylisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C9H7NO2

General procedure: To an 8 mL dram vial was added iodobenzene diacetate (0.6 mmol, 1.5 equiv), arene (0.4 mmol,1 eq.), dichloroethane (2 mL), then 1 M hydrochloric acid (2 mL, 5 equiv). The solution wasallowed to stir (1000 rpm) at 50 C for the indicated amount of time. After which the solution waswashed with saturated sodium bicarbonate, followed by saturated sodium thiosulfate andconcentrated. The crude mixture was then purified by column chromatography.

The synthetic route of 2058-74-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2913-97-5, name is N-(2-Oxoethyl)phthalimide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H7NO3

To a solution of (1 ,3-dioxo-1 ,3-dihydro-isoindol-2-yl)-acetaldehyde (4.53 g) in EtOH (18 mL) was added a solution of 2-aminoethanthiol hydrochloride (2.9 g) in water (3.7 mL) followed by addition in one portion of potassium acetate (2.5 g). The reaction mixture was stirred at rt for 2 h and poured into a sat. NaHCO3 solution, the resulting precipitate was collected by filtration and washed with water and EtOH to yield the title compound as a white solid (4.92 g, 82percent).LC-MS: tR = 0.57 min; [M+H]+ = 248.95

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2913-97-5.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; HAZEMANN, Julien; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; WO2010/4507; (2010); A1;,
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550-44-7, name is 2-Methylisoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 550-44-7

(1) Refer to Figure 2 to determine the microchannel reactor connection mode, remove the preheating zone module, the channel type is cylindrical straight channel and circular microchannel structure, the number of microchannel mixed reaction modules is determined according to the flow rate and residence time.The N-methylphthalimide-concentrated sulfuric acid solution was regarded as the raw material A, the concentrated nitric acid solution was regarded as the raw material B, and the two materials were injected into the reaction zone through the metering pump at a flow rate of 10 ml/min and 25 ml/min, respectively. In the mixed residence reaction, the molar ratio of concentrated nitric acid to substrate is 1.2:1, the mass ratio of substrate to concentrated sulfuric acid is 1:2, and the microchannel reactor of Fig. 2 is used to control the temperature of 60 C, residence time. 180s, the reaction solution was quantitatively collected, washed with ice water, washed with water, filtered, and dried to obtain N-methyl-4-nitrophthalimide nitrated product, HPLC content analysis (normalized) 97%, yield 96 %.

The synthetic route of 550-44-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Wanfeng Chemical Co., Ltd.; Liu Tao; Yao Chenhua; Yu Xingying; Yu Xiaotian; (11 pag.)CN109305933; (2019); A;,
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