Tag: M.W=200-300

Reference of 118289-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Equimolar mixture of 6-chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one 1 (1.00mol) and the carbonyl compound (4i-x) (1.00mol) was stirred at RT in methanol (10mL) for 2h in presence of potassium carbonate (1.20mol). After completion, the reaction mass was filtered to remove inorganic salt, added methanol (10-20mL) and activated charcoal to the filtrate and stirred for 1hr. The crude product was filtered to remove charcoal, methanol was evaporated and cooled to 0-5C to get crude solid. Recrystallized using aqueous ethanol or methanol (Yield 60-70%).

The synthetic route of 6-Chloro-5-(2-chloroethyl)indolin-2-one has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 20780-72-7, name is 4-Bromoisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20780-72-7, Recommanded Product: 20780-72-7

General procedure: A solution of 2-nitrobenzamides 1 or bis(2-nitrobenzamides) 4 (1 mmol), isatins 2 or acenaphthylene-1,2-diones 6 (1 mmol), and SnCl2*2H2O (4 mmol) in EtOH (5 mL) was stirred at reflux for 3-5 h. After this period, the TLC analysis of the mixture showed the reaction to be completed. The mixture was quenched with 3percent HCl (10 mL) and filtered to yield a crude product, which was purified by recrystallization from 95percent ethanol and DMF.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromoisatin, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Bromomethyl)isoindoline-1,3-dione

General procedure: A mixture of 1.02 g (7.4 mmol) of freshly calcined K2CO3, 7.0 mmol of the corresponding 2-thiouracil 1-3 and 7.7 mmol of 2-(bromomethyl)-2Hisoindole-1,3-dione in 20 mL of anhydrous DMF was stirred at room temperature for 72 h. The mixture was filtered, the fi ltrate was evaporated to dryness under reduced pressure. The precipitate of mineral salts on the filter was dissolved in 1 M. aqueous H3PO4 and the resulting solution was combined with the bottom residue. The resulting mixture was filtered. The filtercake was washed with water, and then the filtrate was extracted EtOAc (3×50 mL). The filter cake was air dried to constant weight, and the organic extract was dried over anhydrous MgSO4. The dried organic extract was evaporated to dryness under reduced pressure. The residue was mixed with the filter cake and evaporated in a mixture with toluene (3×50 mL) under reduced pressure. A crude product was obtained in the residue, which was subjected to further purification using preparative HPLC.

The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 132898-96-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132898-96-5, name is 2,3-Dioxoindoline-5-sulfonyl chloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1: 5′-({(2S)-2-[(Benzyloxy)methyl]pyrrolidin-1-yl}sulfonyl)-1H-indole-2,3-dione To a suspension of 2,3-dioxo-2,3-dihydro-1-H-indole-5-sulfonyl chloride (9.33 g, 38.0 mmol) in a 1:1 mixture of CHCl3:THF (410 mL) was added drop-wise a solution of (2S)-2-[(benzyloxy)methyl]pyrrolidine (8.00 g, 41.8 mmol, 1.1 eq) and N,N-diiso-propylethylamine (12.2 mL, 69.8 mmol, 1.8 eq) in chloroform (63 mL) over 1.25 hours with cooling in an ice bath under a dry N2 atmosphere. The reaction was complete (by TLC) after stirring for 1 hour at room temperature. The reaction was concentrated and purified on silica gel eluding with 50/50 Pet ether/EtOAc to give the title compound as a bright orange solid (11.8 g, 77.6% yield). NMR (400 MHz, DMSO-d6): consistent.

The synthetic route of 2,3-Dioxoindoline-5-sulfonyl chloride has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 99365-40-9, name is 6-Bromoindolin-2-one, A new synthetic method of this compound is introduced below., Product Details of 99365-40-9

To the mixture of 6-bromo-2-oxindole (5 g, 24 mmol) (Combi-blocks) and 3-chloro-2-fluorobenzaldehyde (3.7 g, 24 mmol) (Oakwood) in methanol (200 mL) was added piperidine (2 g, 24 mmol) (Aldrich) dropwise. The mixture was then heated at 80 C. for 2 h. After cooled to 4 C., the mixture was filtered and resulting precipitate was collected, dried to give E/Z-6-bromo-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-indol-2-one as a yellow solid (Yield 7.8 g, 94%).

The synthetic route of 99365-40-9 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1-(2,6-Dichlorophenyl)-2-indolinone

General procedure: A finely ground mixture of 5-substituted indole-3-carboxaldehyde (1 mmol) and active methylene compound (indolinone/oxindole/barbituric acid/1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one)/2-trifluoromethylbenzaldehyde (1.2 mmol) was irradiated in microwave oven for 1-5 min. The solid product was washed with diethyl ether and purified by column chromatography to get pure products 2-5 and 11-28 except compound 3. Compound 3 was prepared by treatment of 5-substituted indole-3-carboxaldehyde with indolinone in ethanol-water in presence of NaOH (1.5 mmol).

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference of 3339-73-9,Some common heterocyclic compound, 3339-73-9, name is 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, molecular formula is C11H9NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

30-a: Place 2-TBS-lycoline (1.0 mmol), 3-phthalimidopropionic acid (1.2 mmol), EDCI (1.2 mmol), DMAP (0.12 mmol), 15 ml of dichloromethane, place in In a 50ml reaction flask, stir at room temperature until no raw materials remain. Transfer to a separatory funnel, add 50 ml of dichloromethane, wash the organic phase with saturated sodium bicarbonate solution, water, and saturated sodium chloride solution, dry over anhydrous sodium sulfate, and concentrate for later use.30-b: Put the above product, TBAF (2.0 mmol), 15 ml of THF, into a 50 ml reaction bottle, and stir at room temperature until no raw materials remain. Transfer to a separatory funnel, add 50 ml of dichloromethane, wash the organic phase with saturated sodium bicarbonate solution, water, and saturated sodium chloride solution, dry over anhydrous sodium sulfate, concentrate, and separate by column chromatography to obtain a yellow solid (28.4% ).

The synthetic route of 3339-73-9 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H4F3NO3

General procedure: A mixture of 5,6-dimethoxy-2-[(E)-1-arylmethylidene]-1-indanone (1, 0.364 mmol), thiazolidine-4-carboxylic (3, 0.364 mmol) and 1-morpholinoindoline-2,3-dione (2,0.364 mmol) was dissolved in methanol (1 mL) and irradiated for 2-3.5 min in a CEM microwave synthesizer (100 0C, 100 W). After completion of the reaction as evident from TLC, the mixture was poured into water. The precipitated solid was filtered and washed with water to afford the products 4a-i which was purified by recrystallisation.

The synthetic route of 5-(Trifluoromethoxy)indoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 893620-44-5, name is 6-Bromo-5-fluoroindolin-2-one, A new synthetic method of this compound is introduced below., COA of Formula: C8H5BrFNO

d) 6-Bromo-5-fluoro-1,3,3-trimethylindolin-2-one To a suspension of NaH (5.04 g, 126 mmol) in tetrahydrofuran (105 ml) 6-bromo-5- fluoroindolin-2-one (7.24 g, 31.5 mmol) was added portionwise under an argon atmosphere. After gas evolution had ceased methyl iodide (17.9 g, 7.88 ml, 126 mmol) was added dropwise within 50 minutes by means of a syringe pump (exothermic reaction), keeping the temperature of the reaction mixture between 24 C and 26 C. The reaction mixture was kept at roomtemperature for 4 hours and then carefully quenched with aqueous ammonium chloride solution. The reaction mixture was diluted with tert-butyl methyl ether, water and saturated aqueous ammonium chloride solution. The aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were washed with saturated aqueous ammonium chloride and dried over sodium sulfate. The solvent was evaporated and the residue was triturated with heptane to give the title compound as light brown solid (7.87 g).MS ESI (m/z): 272.1, 274.1 [(M+H)i.H NMR (CDC13, 400 MHz): (ppm) = 7.02-6.97 (m, 2H), 3.19 (s, 3H), 1.36 (s, 6H).

The synthetic route of 893620-44-5 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104618-31-7, name is 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 104618-31-7

A solution of 4-phthalimido cyclohexanol (7.1 g, 0.029 mole) in dichloromethane (250 ml) was treated with pyridinium chlorochromate (8.6 g, 0.04 mole) and the resulting dark mixture was stirred at room temperature overnight. Diethyl ether (50 ml) was added and the mixture filtered through keiselguhr. The filtrate was concentrated in vacuo and the residue purified by column chromatography (SiO2; CHCl3/EtOAc) to give 4-phthalimido cyclohexanone as a white solid (6.4 g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 104618-31-7.