Tag: M.W=200-300

Reference of 5181-35-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5181-35-1 as follows.

To a mixture of 2-(2-bromoetho xy)isoindo line- 1,3- dione (20 g, 74 mmol, prepared according to the procedure described in step 1 of preparation 10) and 2H-tetrazole-5-carboxylic acid ethyl ester (10.51 g, 74 mmol) in dimethylformamide (100 ml) was added cesium carbonate (24.13 g, 74 mmol) lot wise under stirring at room temperature. After 16 hours, the reaction mixture was filtered through filter paper and filtrate was slowly poured into chilled water (700 ml) under stirring. After 30 minutes of stirring, the product was extracted with ethyl acetate (200 ml and 100 ml). The combined organic layers were washed with brine (100 ml). The organic extract was dried over anhydrous sodium sulfate and concentrated in vacuo to yield 12.5 g of the titled compound. The compound was purified by column chromatography using mixture of acetone and hexane as an eluent. The fractions containing the compound were collected and concentrated to provide 10 g of mixture of ethyl l-{2-[(l,3-dioxo- l,3-dihydro-2H-isoindol-2- yl)oxy]ethyl}- lH-tetrazole-5-carboxylate and ethyl 2-{2-[(l,3-dioxo- l,3-dihydro-2H-isoindol-2- yl)oxy]ethyl}-2H-tetrazole-5-carboxylate in 53% yield Analysis: Mass: 332(M+1); for Molecular weight: 331 and for Molecular formula: C14H13N5O5

According to the analysis of related databases, 5181-35-1, the application of this compound in the production field has become more and more popular.

Electric Literature of 959235-95-1,Some common heterocyclic compound, 959235-95-1, name is 6-(Trifluoromethoxy)indoline, molecular formula is C9H8F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

HATU (7.02 g, 18.46 mmol) was added to a mixture of 6-(trifluoromethoxy)indoline [CAS 959235-95-1 ] (2.5 g, 12.3 mmol), 2-(4-chloro-2-fluorophenyl)acetic acid [CAS 194240-75-0] (2.32 g, 12.3 mmol) and diisopropylethylamine (6.1 ml_, 36.9 mmol) in DMF (100 ml_). The resulting mixture was stirred at room temperature for 12 h. The mixture was diluted with water, the precipitate was filtered off, and washed with water. The residue was taken up with EtOAc and the organic solution was washed with a 10% aqueous solution of K2CO3, brine, dried over MgSO , filtered and the solvent was evaporated under reduced pressure. The residue product was crystallized from diisopropyl ether to give 2-(4-chloro-2- fluorophenyl)-1 -(6-(trifluoromethoxy)indolin-1 -yl)ethanone 10a (4 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-(Trifluoromethoxy)indoline, its application will become more common.

923590-95-8, name is 4-Bromoisoindoline hydrochloride, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Bromoisoindoline hydrochloride

To a solution of (2S,4R)-BOC-4-hydroxyproline methyl ester (126.3 g,515 mmol) in DMF (960 mL) at 00C was added N,N’-carbonyldiimidazole (83.51 g, 515 mmol). The reaction mixture was stirred at RT for 3 hours. 4-Bromoisoindoline hydrochloride (12O g, 515 mmol) and DIPEA (96.3 mL, 540 mmol) were added, and the reaction mixture heated to 50C for 6 hours. The reaction mixture was then allowed to cool to RT and stirred overnight. The reaction mixture was partitioned between EtOAc (3 L) and 10% aqueous KHSO4 (6 L), the aqueous re-extracted with EtOAc (2 L) and the combined organic phases washed with 10% aqueous NaHCO3, brine, dried over Na2SO4 and solvent evaporated to a foam (239 g). LRMS (ESI) m/z 471.0 [(M+H)+; calcd for C20H26BrN2O6: 471.1].

The synthetic route of 923590-95-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 6941-75-9

Synthetic Example 3; Synthesis of 4-bromophthalamide (hereinafter abbreviated as 4-BPA); [Show Image] 4-BPA represented by the formula (21) was synthesized from 4-bromophthalimide (hereinafter abbreviated as 4-BPI) according to the following procedure (reaction formula 3) with reference to Journal of Heterocyclic Chemistry, 1995, pp. 495-498. In a 100-ml eggplant flask, 27.8017 g (0.123 mols) of 4-BPI and 60 ml of 20% ammonia water were placed followed by reaction under stirring at 23C for 48 hours. After completion of the reaction, the reaction solution in the form of a white suspension was allowed to stand at 0C for one hour, followed by filtration under reduced pressure. The resulting white solid was dried in a reduced pressure dryer at 23C or 24 hours to obtain 29.90 g (yield: 75%) of a white powder of 4-BPA. The thus obtained white powder was subjected to identification of the structure thereof from NMR spectra and confirmed as 4-BPA. 1H-NMR (ppm/DMSO-d6):delta 7.84(s, 1H), 7.78(s, 1H), 7.67(d, 1H), 7.65(d, 1H), 7.62(d, 1H), 7.43(s, 1H), 7.40(s, 1H).

According to the analysis of related databases, 6941-75-9, the application of this compound in the production field has become more and more popular.

Related Products of 667463-64-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 667463-64-1 name is 6-Bromo-1-methylindoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

I-12.1 (15.0 g, 63 mmol) and hydrazine hydrate (30 mL, 618 mmol) are heated to 125 C. for 72 h. To the cool reaction mixture DCM is added and extracted with water and 1 M HCl. The organic layer is dried over MgSO4 and concentrated. The crystallized residue is dissolved in DCM, methanol is added and the DCM is removed in vacuo. The crystallized product is filtered by suction and washed with cold methanol. Yield 63%, m/z 226/228 [M+H]+, rt 1.16 min, LC-MS Method V001-003.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromo-1-methylindoline-2,3-dione, and friends who are interested can also refer to it.

Related Products of 132898-96-5, These common heterocyclic compound, 132898-96-5, name is 2,3-Dioxoindoline-5-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedure: To a solution of 4 (1.32 g, 5 mmol) in CH2Cl2 (10 mL), trifloroacetic acid (10 mL) was added at 0 oC. The mixture was stirred at 0 oC for 15 min. After evaporation of the solvent in vacuo, CH2Cl2 (15 mL) and triethylamine (2 mL) were added, then a solution of 2,3-dioxoindoline-5-sulfonyl chloride (1.23g, 5mmol) in THF (25 mL) was added at 0 oC. The reaction mixture was stirred overnight at rt. Then the solvent was evaporated in vacuo, ethyl acetate (100 mL) was added, washed with water (50 mL x 2), saturated NaCl (50 mL), and dried over Na2SO4. After evaporation of the ethyl acetate, the crude product was purified by Flash column chromatograph with ethyl acetate to afford 1.27 g (68%) of 5.

The synthetic route of 132898-96-5 has been constantly updated, and we look forward to future research findings.

Reference of 87-48-9, These common heterocyclic compound, 87-48-9, name is 5-Bromoindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of isatin (6a-e, 1.0 g) and hydrazine-hydrate (5 mL,~30 mmol) in ethylene glycol, potassium hydroxide (10 equiv.) was added and the resulting reaction mixturewas stirred at 110-130 C for 2-3 h (reaction monitored by TLC). The reaction mixture wascooled to room temperature, poured into ice-cold water (50 mL), acidified to pH 2 with 6N hydrochloric acid and extracted with ethylacetate (3 30 mL). The organic extracts were combined, washed with brine (15 mL), dried over sodium sulfate and concentrated in vacuo. The obtained residue was purified by column chromatography using ethyl acetate-hexane as eluents to furnish 7a-e in moderate yields.

Statistics shows that 5-Bromoindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 87-48-9.

Adding a certain compound to certain chemical reactions, such as: 111992-61-1, name is 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111992-61-1, Formula: C13H14BrNO2

Step 3A suspension of 3-(4-phenoxyphenyl)-l H-pyrazolo[3,4-d]pyrimidin-4-amine (400 mg, 1.3 mmol, 1.00 equiv), 2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro- lH-isoindole-l ,3- dione (570 mg, 1.95 mmol, 1.50 equiv) and cesium carbonate (847 mg, 2.60 mmol, 2.00 equiv) in NMP (50 mL) was stirred at 100C for 12 h under nitrogen atmosphere. It was quenched with water (150 mL). The resulting solution was extracted with ethyl acetate (5 x 30 mL). The organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column eluting with dichloromethane / methanol (10 / 1 ). This resulted in 280 mg (41 %) of 2-(2-[[4-amino-3-(4-phenoxyphenyl)- lH-pyrazolo[3,4-d]pyrimidin-l -yl]memyl]-2-memylpropyl)-2,3-dihydro-I H-isoindole-l ,3- dione as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6326-79-0, name is 6-Bromoisatin, A new synthetic method of this compound is introduced below., Product Details of 6326-79-0

To a round bottom flask containing 6-bromoindoline-2,3-dione (1 g, 4.42 mrnol) was added NaOH (4.9 mL, 4.87 mmol) and stirred at 50 C for I h. The reaction mixture is then brought to ii and cooled to 0C before adding a solution of NaNO2 (0.31 g, 4.42 mmol) in 1-120 (1 1 mL) dropwise over a period of 15 mins, The above mixture was then added to a solution of H20 (9 mL) and H2S04 (46 mL) thai is precooled to 0 C dropwise over a period of 15 mins. The crude mixture was then added to a mix of cone. HCI (4 mL)and SnC1?.2H20 (2.5 g, 11.06 rnmoi) at ii and continued to stir at rt for I h. The solids are then filtered and dried to give the crude product 6-hromo-IH-indazoie-3-carhoxyiic acid (Intermediate I 12A) (1.1 g, 93%) as a tan solid. The crude product was taken to the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-(Trifluoromethoxy)indoline-2,3-dione

Information Example 2: 5-Trifluoromethoxy-1H-indole Lithium aluminum hydride (10.4 mL,1M in THF, 10.4 mmol) was added to a solution of 5-trifluoromethoxyistatin (0.8 g, 3.45 mmol) in THF at room temperature and the mixture was refluxed overnight. The reaction mixture was cooled, and Na2SO4·10H2O was added very carefully portionwise, followed by ethyl acetate. The reaction mixture was then filtered, and the filtrate was evaporated. The residual oil was purifed by column chromatography with ethyl acetate in hexanes (2:98) to yield 5-trifluoromethoxy-1H-indole (0.162 g, 23%).

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.