Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 320734-35-8, name is 7-Bromooxindole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 7-Bromooxindole

To a solution of 7-bromo-l,3-dihydro-2H-indol-2-one (200 mg, 0.94 mmol) in DMF (5 mL) were added cesium carbonate (676 mg, 2.07 mmol) and iodomethane (294 mg, 2.07 mmol). The reaction mixture was stirred at ambient temperature for 18 h, then partitioned between H2O (50 mL) and EtOAc (100 mL). The organic extract was dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with a gradient of hexane: EtOAc – 100:0 to 85:15, to give the title compound. MS: mlz = 254 (M + 1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 320734-35-8.

Adding a certain compound to certain chemical reactions, such as: 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5332-26-3, Product Details of 5332-26-3

To a stirred solution of 26 (50.0 g, 0.142 mol) in THF (500 mL) was added NaHMDS (2 M in THF, 106.2 mL, 0.213 mol) at 0 C and the resultant mixture was stirred for about 30 min. Then 2-(bromomethyl)isoindoline-1,3-dione (17; 41.0 g, 0.171 mol) was added at 0 C and the resultant reaction mixture was stirred for about 30 min. The reaction mixture was quenched with H2O (500 mL) at 0 C and extracted with EtOAc (2 × 500 mL). The combined organic layers were washed with H2O and brine, and concentrated to get the crude compound of 27, which was purified by column chromatography using PE/EtOAc (8.5:1.5) as eluent to afford the desired compound 27 as a colorless syrup; yield: 51 g (70%). 1H NMR (400 MHz, CDCl3): delta= 7.87-7.84 (m, 2 H), 7.78-7.75 (m, 2 H),7.42-7.33 (m, 5 H), 5.80 (br s, 1 H), 5.25-5.18 (m, 2 H), 4.32 (s, 2 H),4.18 (q, J= 7.2 Hz, 2 H), 3.74-3.61 (m, 2 H), 1.45 (s, 9 H), 1.19 (t, J= 6.8Hz, 3 H). 13C NMR (100 MHz, CDCl3): delta= 168.6, 168.5, 168.4, 155.5, 135.4,134.4, 131.6, 128.4, 128.3, 128.2, 123.7, 123.6, 79.3, 67.6, 62.1, 57.6,40.9, 38.7, 28.3, 13.7.LCMS: m/z= 511 [M + 1]. HRMS: m/z[M]+calcd for C27H31N2O8+: 511.2075; found: 511.2068.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18711-15-4, name is 4,6-Dichloroisatin, A new synthetic method of this compound is introduced below., Product Details of 18711-15-4

Example 15,7-Dichloro-4-(5-chloro-2-methoxyphenyl)-3-hydroxy-2(1H)-quinolinone and its regioisomer 5,7-dichloro-3-(5-chloro-2-methoxyphenyl)-4-hydroxy-2(1H)-quinolinone A mixture of 4,6-dichloro-1 H-indol-2,3-dione (6.48 g, 0.03 mol), 5-chloro-2-methoxy-[N-(4-methylphenyl)hydrazonomethyl]phenyl (10.65 g, 0.0315 mol, 1.05 eq.) and NaOMe (90 mL of 1.0 M solution in methanol) in methanol (150 mL) was heated at reflux temperature for 3 hours. The reaction mixture was cooled and the solid was collected by filtration and washed with methanol (3 x 10 mL). The solid was suspended in 0.5 N HCl solution (500 mL), stirred for 20 minutes then filtered, washed with water (3 x 50 mL) and dried to yield 2.76 g of the desired isomer 5,7-dichloro-4-(5-chloro-2-methoxyphenyl)-3-hydroxy-2(1H)-quinolinone.1H NMR (300 MHz, DMSO-d6) delta: 7.39 (dd, 1H, J = 2.7, 8.8 Hz), 7.36, (1H, d, J = 2.2 Hz), 7.23 (1H, d, J = 2.2 Hz), 7.15 (1H, d, J = 2.2 Hz), 7.02 (1H, d, J = 8.9 Hz), 3.64 (3H, s), 12.53 (1H, bs), 9.79 (1H, bs).13C NMR (75 MHz, DMSO-d6) delta: 157.2, 156.0, 145.4, 135.4, 130.2, 130.0, 130.0, 128.8, 126.3, 124.5, 123.6, 118.5, 116.6, 114.4, 112.2, 55.7. UV(abs. ethanol at 5.2 x 10-4 g/100 mL) lambdamax: 232 (1107), 336 (299) , 288 (292), 322 (289) and 310 (221); MS (DCI): 370 (MH+); IR (KBr, cm-1): 3500-2400, 1665, 1300-1200 and 1020. [] Anal. calcd. for C16H10Cl3NO3 C, 51.85;H, 2.72;N, 3.78.FoundC, 51.89;H, 2.81;N, 3.74. The filtrate from the above reaction mixture was added to 0.5 N HCl solution (1500 mL) with stirring. The product which precipitated from the acidified mixture was collected by filtration and dried to yield 8.11 g of a mixture (6:1) of the regioisomer 5,7-dichloro-3-(5-chloro-2-methoxyphenyl)-4-hydroxy-2(1H)-quinolinone and some of the desired product. A sample of the purified regioisomer had the following characteristics:1H NMR (300 MHz, DMSO-d6) delta: 11.70 (1H, s), 10.08 (1H, s), 7.37 (1H, dd, J = 2.7, 8.9 Hz), 7.29 (2H, d, J = 1.6 Hz), 7.13 (1H, d, J = 2.6 Hz), 7.05 (1H, d, J = 8.9 Hz), 3.68 (3H, s);13C NMR (75 MHz, DMSO-d6) delta: 156.9, 141.2, 134.3, 132.2, 131.6, 128.9, 124.1, 123.6, 113.8, 113.1, 55.7; UV(abs. ethanol at 4.8 x 10-4 g/100 mL) lambdamax: 234 (1480), 296 (373) and 326 (300) nm; MS (DCI): 370 (MH+); IR (KBr, cm-1): 3500-2500, 1660 and 1250. [] Anal. calcd. for C16H10Cl3NO3 C, 51.85;H, 2.72;N, 3.78.FoundC, 52.01;H, 2.76;N, 3.80.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 435273-55-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 435273-55-5 as follows.

Example 2: Synthesis of 5,6-dimethyldibenzo[crfj/lindol-4(5//)-one; 4-Bromo-2-methylisoindolin-l-one (60 mg, 0.26 mmol) obtained in Step 3 of Example 1, 2-acetylphenylboronic acid (51 mg, 0.32 mmol), tetrakis(triphenylphosphine)palladium (12 mg, 0.01 mmol), 2- (dicyclohexylphosphino)-2′-(N,N-dimethylamino)biphenyl (8 mg, 0.02 mmol) and cesium carbonate (259 mg, 0.80 mmol) were dissolved in a 1 m. of ethanol-2 mNo. toluene mixture and placed in a vessel. The vessel was sealed using a septum, and heated for 5 min at 120C and for 10 min at 150C is a microwave reactor and cooled to room temperature. The reaction mixture was filtered through a cellite column while washing with ethyl acetate, and the solvent was evaporated under a reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 5,6- dimethyldibenzoindol-4(5H)-one (52 mg (77%)).1H NMR (300 MHz, CDCl3) delta 8.56-8.53 (m, 2H), 8.08-8.05 (m, 2H), 7.79-7.76 (m, IH), 7.65-7.59 (m, 2H), 3.75 (s, 3H), 2.84 (s, 3H).

According to the analysis of related databases, 435273-55-5, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H4F3NO3

General procedure: A mixture of beta-nitrostyrenes, isatin and tyrosine (1:1:1) was stirredunder heating at 100 C for 1 h in [bmim]Br (200 mg). After the reaction was completed, 10 mL of ethyl acetate was added to the reaction mixture and stirred for 15 min. The organic layer was separated, washed with water, and dried. The cycloadduct was further purified using hexane: ethyl acetate (3:2 v/v) as eluent employing column chromatography technique. After extraction of the cycloadduct, [bmim]Br wasdried under vacuum at 80 C for 2 h to exclude any water trapped from moisture and reused for subsequent runs.

The synthetic route of 5-(Trifluoromethoxy)indoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Electric Literature of 959235-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 959235-95-1, name is 6-(Trifluoromethoxy)indoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-((3-(4-(fe/t-butoxy)-4-oxobutoxy)-5-nnethoxyphenyl)annino)-2-(2- (2-((fe/t-butyldinnethylsilyl)oxy)ethoxy)-4-chlorophenyl)acetic acid 8d (675 mg, 1.08 mmol) in DMF (6 ml_) were added HATU (617 mg, 1.62 mmol),diisopropylethylamine (536 muIota_, 3.24 mmol) and 6-(trifluoromethoxy)indoline [CAS 959235-95-1] (220 mg, 1.08 mmol). The reaction mixture was stirred at room temperature for 7 days. The reaction mixture was diluted with water. The precipitate was filtered off, washed with water and taken up with EtOAc. The organic layer was washed with a 10% solution of K2CO3 and water, dried over MgSO4, filtered and the solvent was concentrated under reduced pressure to give terf-butyl 4-(3-((1 -(2-(2-((fe/t-butyldimethylsilyl)oxy)ethoxy)-4-chlorophenyl)-2-oxo- 2-(6-(trifluoromethoxy)indolin-1 -yl)ethyl)amino)-5-methoxyphenoxy)butanoate 8e (385 mg). The compound was used without further purification in the next reaction step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-(Trifluoromethoxy)indoline, other downstream synthetic routes, hurry up and to see.

Related Products of 201940-08-1, The chemical industry reduces the impact on the environment during synthesis 201940-08-1, name is tert-Butyl 5-bromoisoindoline-2-carboxylate, I believe this compound will play a more active role in future production and life.

5-Bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (2.97 g, 10 mmol) was azeotropically dried by evaporation from toluene. Tris(dibenzylideneacetone)dipalladium (0) (228 mg, 0.25 mmol), 2-(di-tert-butylphosphino)biphenyl (149 mg, 0.50 mmol) and sodium tert-butoxide (1.34 g, 13.9 mmol) were added and the flask was purged with nitrogen. Toluene (25 mL) then N-methylpiperazine (1.33 mL, 12 mmol) were added and the mixture was heated to 8O0C for 2 hours. After allowing to cool to r.t. the mixture was diluted with ether, filtered through Celite and concentrated to give a residue that was purified by flash chromatography on silica (2M methanolic ammonia/dichloromethane, 1% to 3% gradient). This afforded the title compound as a brown solid (1.45g, 46%). 1H NMR (MeOH-d4) 7.15 (1H, m), 6.94-6.88 (2H, m), 4.60-4.54 (4H, m), 3.20-3.17 (4H, m), 2.63-2.60 (4H, m), 2.34 (3H, s), 1.52 (9H, s). MS: [M+H]+ 318.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 5-bromoisoindoline-2-carboxylate, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 6326-79-0, name is 6-Bromoisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 6-Bromoisatin

General procedure: The targeted compounds have been synthesized as previouslydescribed (38). This approach consists in the couplingof a correctly substituted isatin and the 3-acetoxyindole inalkaline methanol to afford the indirubin skeleton. Then, the3¢-position reacts with hydroxylamine in refluxing pyridine leading to the corresponding indirubin-3¢-oxime. To a solutionof the corresponding indirubin in pyridine, hydroxylaminehydrochloride was added. The mixture was warmed inreflux for 1.5 h. After completion and cooling to 70C, waterwas added. The resulting precipitate was filtered, washedwith water and cyclohexane, and dried to afford the correspondingoxime as a red solid with 100%.796 was synthesized after acetylation of the oxime as waspreviously described (38) and was obtained with 100% yield.For synthesis of 6BIO-Pip, the corresponding indirubin-3¢-oxime was dissolved in anhydrous dimethylformamide(DMF). Then, 1,2-dibromoethane and a catalytic amount oftriethylamine were added and the mixture was stirred at 50Cfor 24 h. After completion, water was added and the precipitatefiltered, washed with water, and dried. The ether wasdissolved in anhydrous DMF. The corresponding amine wasthen added and the resulting mixture was warmed at 80Cunder a radiation of 150W for 20 min. After completion,water is added and the resulting precipitate is filtered, washedwith water, and dried. The corresponding derivatives areobtained as purple solid.

The synthetic route of 6-Bromoisatin has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2058-72-2

General procedure: To a stirring mixture of catalyst 1a (0.005 mmol) and cyclohexanone/acetone (5 mmol) in water (500 muL), additive DNP (0.920 mg, 0.005 mmol) was added at 25 C and the mixture was allowed to stir for 5 min followed by addition of isatin derivative (0.5 mmol). The mixture was stirred for 20-96 h and the progress of the reaction was monitored at regular intervals by TLC. On the completion of reaction, saturated solution of NH4Cl (5 mL) was added to it and resulting mixture was extracted with ethyl acetate (3×15 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain crude aldol product. The column chromatography on silica gel (60-120 mesh) using hexane/ethyl acetate as an eluent gave the corresponding aldol adducts as a syn/anti mixture. The enantiomeric excess of aldol addition products was determined by chiral HPLC. The diastereoselectivity of product was determined by HPLC of crude reaction mixture. Racemic standards were prepared using (±) 3-methyl-1-morpholinobutan-2-amine catalyst synthesized form (±) valine.

The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.

Reference of 5332-26-3, A common heterocyclic compound, 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, molecular formula is C9H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Benzimidazole (1 mmol) and potassium hydroxide (1 mmol) were dissolved in ethyl alcohol (60 mL). The alkyl halide (1 mmol) was slowly added after the obtained reaction mixture was stirred at room temperature for 1 h. The solution was refluxed for 6 h, cooled to roomtemperature and the precipitated potassium chloride was removed by filtration. The solvent was removed by distillation. The product was then crystallized, washed several times with diethyl ether and then dried in vacuo. To a solution of 1-alkylbenzimidazole (1 mmol) in dried DMF (4 mL), alkyl halide (1 mmol) was added slowly and the reaction mixture was stirred at 80 C for 24 h under argon. After completion of the reaction, the DMF was removed by vacuum and diethyl ether (15 mL) was added to the mixture. The solid was washed with diethyl ether (2 × 15 mL) and dried under vacuum. The product was crystallized in an ethanol/diethyl ether mixture (3:1) at room temperature. The purified compounds were obtained as white or cream solids. Their structures were characterized by NMR (1H and 13C), FTIR, ESI-FTICR-MS (for 2 and 4) spectroscopic methods and elemental analysis

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.