Tag: M.W=200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 675109-26-9, name is 6-Bromoisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 6-Bromoisoindolin-1-one

General procedure: Bromoisoindolin-1-one (2.0 g, 9.43 mmol) was dissolved with warming in DMF (150 mL),then cooled to 0C. NaH (415 mg, 10.4 mmol) was added and the mixture stirred under N2 at 0C for 0.5 h. Methyl iodide (0.65 mL, 10.4 mmol) was added dropwise and the reaction allowed to warm to room temperature and stir for another I h. A small quantity of water was added to quench the reaction then the DMF removed under reduced pressure to give an oily yellow residue which was dissolved in EtOAc (150 mL). This solution waswashed with water (3×100 mL), brine (100 mL) and dried (Na2SO4)., Removal of the solvent under reduced pressure gave a solid which was purified by filtration through a plug of silica gel (10% acetone/CH2C12 as eluant). The title compound was isolated as a very pale yellow crystalline solid (1.64 g, 80%). ? H NMR [400 MHz, (CD3)2S0] oe 7.85 (dd, J= 1.5, 0.6 Hz, 1 H), 7.66 (dd, J= 8.0, 1.7 Hz, 1 H), 7.59 (d, J- 8.0 Hz, I H), 4.46 (s,2 H), 3.05 (s, 3 H). LRMS (APCI) calcd for C9H8BrNO 226, 228 (MH), found 226, 228.

The synthetic route of 675109-26-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 90725-50-1, A common heterocyclic compound, 90725-50-1, name is 6-Bromo-3-methylindolin-2-one, molecular formula is C9H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6-bromo-3 -methyl- 1, 3 -dihydro-2H-indol-2-one A.20 (15g, 66.35mmol) was combined with 70ml of acetic anhydride. The solution was heated at 1100C for 2 days before it was concentrated under vacuum. The oil obtained was diluted with ethyl acetate and washed in succession with saturated NaHCO3, water, and brine. The organics were dried over MgSO4 before they were concentrated under vacuum. The residue obtained was heated in EtOH (80ml) to form a clear reddish solution. After cooling to -150C and standing overnight, a light brown solid was collected by filtration as 1 -acetyl-6-bromo-3 -methyl- 1,3 -dihydro-2H-indol-2- one A.26 (8.8g, 50%) .IH NMR (500 MHz, DMSO-d6) delta ppm 8.25 (1 H, d, J=I.5 Hz), 7.43 (1 H, dd, J=7.8, 1.4 Hz), 7.38 (1 H, d, J=8.3 Hz), 3.78 (7 H, q, J=7.3 Hz), 2.56 (3 H, s), 1.42 (3 H, d, J=7.8 Hz).

The synthetic route of 90725-50-1 has been constantly updated, and we look forward to future research findings.

Related Products of 169037-23-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of indoline-2,3-dione 1 (1mmol), l-tryptophan (2a) or l-histidine 2b (1mmol) and (E)-(2-nitrovinyl)benzene 3 (1.1mmol) was heated while stirred in [bmim]Br as the reaction medium (3mL) for 1hat 100C. After completion of the reaction (TLC), EtOAc (5mL) was added and the reaction mixture was stirred for 10min. This treatment was repeated and the combined ethyl acetate layers were removed in vacuo. The crude product was purified by recrystallization of the residue from EtOH (compounds 4) or by column chromatography (compounds 5). After extraction of the product, the ionic liquid was dried under vacuum at 80C for 2h to eliminate any water and could be reused for subsequent runs of the reaction.

The chemical industry reduces the impact on the environment during synthesis 5-(Trifluoromethoxy)indoline-2,3-dione. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 153072-43-6 as follows. Recommanded Product: Methyl 2,3-dioxoindoline-4-carboxylate

To a chloroform solution (9 ml) of methyl 2,3-dioxo-2,3-dihydro-1H-indole-4-carboxylate (726 mg, 3.54 mmol), N,N-diethylaminosulfur trifluoride (1.16 ml, 8.85 mmol) was added and the resulting mixture was stirred at room temperature for an hour. To the reaction mixture, a saturated aqueous solution of sodium hydrogencarbonate was added under cooling with ice to arrest the reaction and after rendering the mixture acidic with a saturated aqueous solution of ammonium chloride, extraction was conducted. The organic layer was dried and then concentrated under reduced pressure. The resulting residue was purified with a silica gel cartridge (hexane/ethyl acetate=60:40 to 0:100). As a result, the titled compound was obtained as a pale yellow powder in an amount of 136 mg (yield: 17%). (ESI neg.) m/z: 226 (M-H)-

According to the analysis of related databases, 153072-43-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5181-35-1, name is 2-(2-Bromoethoxy)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 5181-35-1

To a clean dry flask containing suspension of 2-(2-bromoethoxy)isoindoline- l,3-dione (30 g, 0.111 mol), 1H- 1,2,3 triazole (7.66 g, 111 mmol) in dimethylformamide (150 ml) was added cesium carbonate ((36 g, 111 mmol) portion wise at room temperature under stirring. After 17 hours, the reaction mixture was filtered and filtrate was slowly poured into chilled water (1050 ml) under stirring. After 30 minutes of stirring, the separated precipitates were collected by filtration and washed with water (100 ml). The collected precipitates were dried at 40 C for 2 hours under high vacuum to obtain 18.5 g of a mixture of 2-[2-(2H- l,2,3-triazol-2-yl)ethoxy]- lH-isoindole- l,3(2H)-dione and 2-[2- (lH- l,2,3-triazol- l-yl)ethoxy]- lH-isoindole- l,3(2H)-dione as a white compound in 65% yield. Analysis: Mass: 259.2 (M+l); for Molecular weight: 258 and Molecular formula: C12H10N4O3

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18711-13-2 as follows. category: indolines-derivatives

General procedure: Sulfonated-beta-cyclodextrin (beta-CD-SO3H) (76 mg, 0.06 mmol) was dissolved in water (5 mL) at RT by stirring to get the clear solution in 50 mL round bottom ask. Further, isatin 2 (0.31 mmol) and tryptamine 1a/isotryptamine 1b (0.31 mmol) were added to the solution under constant stirring and mixture was heated at 80 C for 8-12 h. The progress of the reaction was monitored by TLC. After completion of reaction, it was cooled to room temperature, water was added to it. The aqueous phase was extracted with ethylacetate. The organic extracts were combined, washed with brine and dried over sodium sulfate. The solvent was evaporated in vacuo and the crude product obtained was puried by column chromatography using chloroform/methanol (99:1) as an eluent furnishing the product. The spectral and analytical data of all the reported products is consistent with the previous (6c,d,f) reports.

According to the analysis of related databases, 18711-13-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(Trifluoromethoxy)indoline-2,3-dione

General procedure: N-(4-Sulfamoylphenyl)hydrazinecarbothioamide (2) (3.5mmol) was added to a solution of 1H-indole-2,3-diones 3a-m (3.5mmol) in ethanol (20mL). After addition of a drop of concentrated sulfuric acid, the mixture was refluxed on a water bath for 4h. The product formed after cooling was filtered and washed with ethanol or recrystallized from ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 675109-26-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 675109-26-9, name is 6-Bromoisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a degassed solution of 6-bromoisoindolin-1-one (0.7 g, 3.3 mmol), 1-Boc pperazine (0.921 g, 4.9 mmol) and sodium tert butoxide (0.95 g, 2.5 mmol) in toluene (10 mL),Pd2(dba)3 (0.151 g, 0.l6Smmol) and BINAP (0.205 g, 0.33 mmol) were added at rt and heated to 80 C overnight in sealed tube. Then the reaction mixture was filtered through celite and concentrated. Water (4 mL) was added and was extracted with EtOAc (2 x 10 mL). The combined organic layer was dried over Na2SO4 and concentrated under vacuum. The resulting crude product was purified by flash chromatography (Eluent: 5-6% MeOH inDCM). After evaporation, the resulting solid was triturated in Et20 and filtered, affording the title product (white solid). 1H NMR (400 MHz, CDCI3): 6 8.72-8.70 (m, IH), 7.79 (d, J = 1.6 Hz, IH), 7.56 (d, J = 8.4 Hz, IH), 7.26-7.23 (m, IH), 4.26 (5, 2H), 3.49-3.46 (m, 4H), 3.18- 3.13 (m, 4H), 1.43 (5, 9H). LCMS: (Method A) 318.0 (M+H), Rt. 2.26 mm, 39.9% (Max).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromoisoindolin-1-one, other downstream synthetic routes, hurry up and to see.

Application of 883-44-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 883-44-3, name is 2-(3-Hydroxypropyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A 50 ml round bottom flask was charged with aq. NaHCO3(0.05 M, 10 ml), aq. K2CO3(0.5 M, 10 ml) and CHCl3(5 ml). Alcohol 5 (16.02 g, 78.1 mmol) was dissolved in CHCl3(50 ml) and transferred to the reaction mixture followed by tetra-nbutylammonium chloride (4.34 g, 15.6 mmol), N-chlorosuccinimide (20.9 g, 156.1 mmol) and TEMPO (2.44 g, 15.6 mmol) and the reaction mixture was stirred vigorously at rt for 4.5 h. The phases were separated and the organic phase was washed with sulfate buffer (100 ml), NaHCO3(100 ml), and brine (100 ml), dried (Na2SO4), filtered and concentrated in vacuo. Purification by flash column chromatography (35% EtOAc in n-heptane, v/v) gave aldehyde 9 (6.54 g, 38%) as a white amorphous solid.

The synthetic route of 2-(3-Hydroxypropyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6941-75-9 as follows. Safety of 5-Bromoisoindoline-1,3-dione

To a solution of 5-bromophthalimide (44.2 mmol; 1.0 equiv) in THF (221 mL) under N2 atmosphere is added BF3-OEt2 (265.5 mmol; 6.0 equiv) and the reaction is stirred for 30 minutes at 25 C. BH3-THF (353.6 mmol; 8.0 equiv) is added to the reaction mixture which is then heated to 40 C for 24 h. The reaction is cooled to room temperature and quenched with 60 mL MeOH until gas evolution ceases; 400 mL HCl is added and the reaction is refluxed for 3 h. The reaction is then cooled to room temperature and the water layer is washed with ethyl acetate. The water layer is then brought to pH 14 with 6 N NaOH and extracted with ethyl acetate. The combined organic extracts are dried (MgSO4), filtered, and concentrated to crude product 5-bromo-2,3-dihydro-lH-isoindole, which is carried onto the next step without further manipulation.

According to the analysis of related databases, 6941-75-9, the application of this compound in the production field has become more and more popular.