Tag: M.W=200-300

959235-95-1, name is 6-(Trifluoromethoxy)indoline, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 6-(Trifluoromethoxy)indoline

To a solution of 2-(2-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-4-fluorophenyl)-2-((3- methoxy-5-(methylsulfonyl)phenyl)amino)acetic acid 2d (1 g, 1 .90 mmol) in DMF (10 mL) were added HATU (1 .08 g, 2.84 mmol), diisopropylethylamine (940 pL,5.69 mmol) and 6-(trifluoromethoxy)indoline [CAS 959235-95-1] (385 mg, 1.90 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with water. The precipitate was filtered off, washed with water and taken up with EtOAc. The organic layer was washed with a 10% solution of K2003 in water, a saturated solution of NaCI in water, water, dried over MgSO4,filtered and the solvent was concentrated under reduced pressure to give 2-(2-(2-((tert-butyld imethyl silyl )oxy)ethoxy)-4-fl uorophenyl )-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1 -(6-(trifluoromethoxy)indolin-1 -yl)ethanone 3a(1 .32 g). The crude compound was used without purification in the next reactionstep.

The synthetic route of 959235-95-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 99365-40-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 99365-40-9, Name is 6-Bromoindolin-2-one, SMILES is O=C1NC2=C(C=CC(Br)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Gobinath, Perumal, introduce new discover of the category.

In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1H-spiro [acridine-9,2 ‘-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, H-1-NMR, C-13-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound 1c was more effective (GI(50) 0.01 mu m) against MCF-7 cancer cell lines than standard and other compounds. Therefore, the objective of this study was achieved with a few promising molecules having been demonstrated to be potential anticancer agents.

Synthetic Route of 99365-40-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 99365-40-9.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Reference of 161596-47-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Huang, Jiann-Jyh, introduce new discover of the category.

In this study, we reported the inhibition profiles of 4 ‘-acylpyrrole-5-fluoroindolin-2-one 3 with a C-3 ‘ side chain for VEGFR2, PDGFR-beta, and FGFR-1 protein kinases. The pyrrole-fused cyclohexanone moiety provided 3 with the best potency to inhibit the three kinases, and the C-3 ‘ side chains contributed to the different inhibition profiles of 3. Compound 3b with a C-3 ‘ 2-carboxylethyl side chain showed good potency for the three kinase (IC50: 25-260 nM), and compound 3g with a N,N-dialkyl-2-carbamoylethyl side chain was more active for VEGFR2 (IC50: 59 nM) and PDGFR-beta (IC50: 16 nM) than FGFR-1 (IC50: 1.7 mu M). The C-3 ‘ 3-(dialkylamino)propyl side chain accomplished 3h-j as selective PDGFR-beta inhibitors (IC50: 7.8-13 nM). Compound 3b was further investigated and found potent to inhibit VEGF- and FGF-dependent cell proliferation with moderate in vivo anticancer activity. Results from docking simulations revealed that the interactions of 3b with VEGFR2 and FGFR-1 which could account for the different inhibition profiles of 3.

Reference of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 320734-35-8, name is 7-Bromooxindole belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 320734-35-8

2-[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2yl)-phenyl]propyl-2-propanesulfonamide (0.174 g, 0.47 mmol), 7-bromo-1,3-dihydro-indol-2-one (0.110 g, 0.52 mmol), PdCl2(dppf).CH2Cl2(0.039 g, 0.048 mmol), and 2 M Na2CO3 (2.5 mL, 5.0 mmol) were combined in dry DMF (5.0 ml) and heated at 80 C. under nitrogen for 8 h. The reaction mixture turned a dark red violet after 1 h. It was then stirred at ambient temperature for 23 h. The reaction mixture was poured into H2O (20 mL) and acidified with aq. HCl. A black sludge formed immediately. The mixture was decanted from the sludge and the sludge was extracted with Et2O (4×20 mL). The combined organic layers were washed with H2O 2×20 mL), dried (Na2SO4), filtered, and evaporated in vacuo. Chromatography of the resulting oil on the Chromatotron using a 1 mm plate and eluting with EtOAc-hexane (1:1) gave the final title compound (0.068 g, 39%) as an orange red glass. MS(ES) 373 (M+1)

The synthetic route of 320734-35-8 has been constantly updated, and we look forward to future research findings.

Reference of 104618-32-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104618-32-8, name is 2-(4-Oxocyclohexyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

Example 14 3-Amino-6-n-butyloxy-1,2,3,4-tetrahydrocarbazole oxalate Reaction of 4-phthalimidocyclohexanone (1.12 g) with 4-n-butyloxyphenyl hydrazine hydrochloride (1.00 g) and subsequent deprotection by the method described in example 3, gave the title compound free base. This was treated with oxalic acid to give the oxalate salt (0.47 g), mp 227 – 229C.

The chemical industry reduces the impact on the environment during synthesis 2-(4-Oxocyclohexyl)isoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 99365-40-9, name is 6-Bromoindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6-Bromoindolin-2-one

n-Butyl lithium (2.5 M in hexanes, 3.8 mL, 9.5 mmol) was added dropwise over 30 minutes to a stirred suspension of 6-bromoindolin-2-one (preparation 1, 1.00 g, 4.7 mmol) and N,N,N’,N’-tetramethylethylenediamine (1.42 mL, 9.4 mmol) in tetrahydrofuran (20 mL) at – 78 C. The mixture was stirred for 1 hour, then 1,4-diiodobutane (3.11 mL, 23.6 mmol) was added dropwise over 5 minutes. The mixture was warmed to -20 C over a 1 hour period, was stirred for a further hour at this temperature and was then warmed to room temperature. After 3 hours stirring at room temperature, saturated aqueous ammonium chloride solution was added to the reaction and the mixture was extracted with ethyl acetate. The organic layer was washed with water, brine, dried (MgSO4) and evaporated. Purification of the residue by flash chromatography (10:1 hexanes/ethyl acetate) gave the title compound (0.57 g, 45%) as a pale pink solid. LRMS (m/z): 266/268 (M+1)+. 1H-NMR delta (CDCl3): 1.81-2.20 (m, 8H), 7.02-7.06 (m, 2H), 7.14-7.18 (m, 1H), 7.83 (br s, 1H).

The synthetic route of 6-Bromoindolin-2-one has been constantly updated, and we look forward to future research findings.

Related Products of 6326-79-0,Some common heterocyclic compound, 6326-79-0, name is 6-Bromoisatin, molecular formula is C8H4BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 6-bromoindoline-2,3-dione (0.504 g,2.23 mmol)in acetonitrile (11 mL)was added K2C03 (1.23 g,8.92 mmol)then iodomethane (0.278 mL,4.46 mmol). The reactionmixture was heated at 60 oc for 1.5 h. After cooling to room temperature,water (30 mL)wasadded and the mixture was extracted with DCM (30 mL x 3). The combined organic layers were washed with brine (30 mL),dried over anhydrous Na2S04 and then concentrated in underreduced pressure to give the title compound (0.506 g,95%)that required no further purification.1HNMR(400MHz,CDCl3)87.46(dd,J=7.9,l.OHz,1H),7.32-7.28(m,1H),7.08(d,J=1.5 Hz,1H),3.25 (d,J = 0.6 Hz,3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromoisatin, its application will become more common.

Reference of 3783-77-5, A common heterocyclic compound, 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione, molecular formula is C12H11NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Synthesis of N-[3-(N-hydroxyimino)butyl]-phthalimide 1.08 g (5.00 mmol) of N-(3-oxobutyl)phthalimide was dissolved in 10 ml of methanol and to the solution was added 0.695 g (10.0 mmol) of hydroxylamine hydrochloride. To this suspension was added 2 ml of 5N aqueous sodium hydroxide solution, followed by being stirred at room temperature for 16 hours. The reaction mixture was poured into 100 ml of saturated aqueous sodium hydrogencarbonate and extracted with chloroform (30 ml*3), and the combined organic layer was dried over magnesium sulfate. Chloroform was distilled off and the residual solids were washed with hexane to give 0.98 g (yield 84%) of the titled compound as colorless crystals. Melting point 151-172 C., 1 H-NMR spectrum (DMSO-d6, TMS as internal standard); delta=1.81(s, 3H*0.75), 1.83(s, 3H*0.25), 2.3-2.6(m, 2H), 3.78(t, J=6 Hz, 2H*0.75), 3.91(t, J=6 Hz, 2H*0.25), 7.85(s, 4H), 10.15(bs, 1H*0.75), 10.34(s, 1H*0.25)ppm,

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 6780-38-7, name is 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride, molecular formula is C10H6ClNO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride

To a solution of the starting material 5-2 (50 mg, 0.2 mmol) and triethylamine (60 mul_, 2 eq) in 1 mL of dioxane at 0 0C was added phthalyl-glycyl chloride (44 mg, 1 eq) in 1 ml_ of dioxane. The resulting solution was stirred at room temperature overnight. The solution was then evaporated. Water was added and the product was extracted in ethyl acetate (X3) to give 77 mg (88% yield) of 11a, LC-MS 440 (MH+). This material was converted to the free amine 11-1 as described in Step 4C. LC-MS (method 2) 310.1 (MH+), tR = 3.44 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6780-38-7, its application will become more common.

Synthetic Route of 200049-46-3, The chemical industry reduces the impact on the environment during synthesis 200049-46-3, name is 7-Bromo-2,3-dihydro-isoindol-1-one, I believe this compound will play a more active role in future production and life.

Similar to the procedure used to prepare Compound 32, Compound Ic was reacted with Compound 12a and Pd(OAc)2, P(?-tolyl)3, and 2N aqueous Na2CO3 in DMF to give Compound 23 as a clear, colorless oil. 1H NMR (400 MHz, CDCl3) 1.30 and 1.65 (rotamer A and B, two singlets, 9H), 4.42 (s, 2H), 6.25 (m, IH), 7.35-7.65 (complex, 5H); MS (ESI) m/z: 299 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2,3-dihydro-isoindol-1-one, other downstream synthetic routes, hurry up and to see.