13861-75-1, name is Spiro[cyclopropane-1,3′-indolin]-2′-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C10H9NO
Example 3 1′-((1-isopentyl-1H-benzo[d]imidazol-2-yl)methyl)spiro[cyclopropane-1,3′-indolin]-2′-one A dried flask under nitrogen was charged with sodium hydride (120 mg, 3.0 mmol) and DMF (1 mL). This rapidly stirred suspension was cooled to 0 C. using an ice/water bath and spiro[cyclopropane-1,3′-indolin]-2′-one (160 mg, 1.0 mmol, Preparatory Example 4) was added dropwise as a solution in DMF (2 mL). The ice/water bath was removed for 15 minutes before the mixture was recooled to 0 C. and 2-(chloromethyl)-1-isopentyl-1H-benzo[d]imidazole hydrochloride (236 mg, 1.0 mmol) was added dropwise as a solution in DMF (2.1 mL). The mixture was allowed to warm to rt and stirred there for 16 hours. The mixture was cooled to 0 C. and ice was added carefully. Partition between EtOAc and water was followed by separation, drying and concentration in vacuo. Preparative HPLC gave isolation of the desired compound, (110 mg, 0.31 mmol, 31%). 1H NMR (400 MHz): delta 0.96 (d, 6H), 1.45 (m, 2H), 1.60 (m, 2H), 1.69 (m, 1H), 1.82 (m, 2H), 4.26 (m, 2H), 5.35 (s, 2H), 6.83 (d, 1H), 7.02 (dd, 1H), 7.19 (dd, 1H), 7.29 (m, 3H), 7.47 (d, 1H), 7.81 (m, 1H). LC/MS 360 (MH+).
The synthetic route of 13861-75-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; re: Viral Ltd; Cockerill, Stuart; Pilkington, Christopher; Lumley, James; Angell, Richard; Mathews, Neil; US2014/308282; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem