Adding a certain compound to certain chemical reactions, such as: 435273-55-5, name is 4-Bromo-2-methylisoindolin-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 435273-55-5, HPLC of Formula: C9H8BrNO
Adding a certain compound to certain chemical reactions, such as: 435273-55-5, name is 4-Bromo-2-methylisoindolin-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 435273-55-5, HPLC of Formula: C9H8BrNO
; 4-Bromo-2-methylisoindolin-l-one (60 mg, 0.26 mmol) obtained in Step3, 2-formylphenylboronic acid (48 mg, 0.32 mmol), tetrakis(triphenylphosphine)palladium (12 mg, 0.01 mmol) and cesium carbonate (259 mg, 0.80 mmol) were dissolved in a 1 mi ethanol-2 mi toluene mixture and placed in a vessel. The vessel was sealed using aseptum, and heated for 10 min at 150C in a microwave reactor and cooled to room temperature. The reaction mixture was filtered through a cellite column while washing with ethyl acetate, and the solvent was evaporated under a reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 5-methyldibenzoindol-4(5H)-one (62 mg (99%)).1H NMR (300 MHz, CDCl3) delta 8.62-8.51 (m, 2H), 8.12-8.08 (m, IH), 7.90-7.80 (m, 2H), 7.65-7.54 (m, 2H), 7.10 (s, IH), 3.52 (s, 3H).
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Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; WO2009/51417; (2009); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem