Application of 1914-02-9, A common heterocyclic compound, 1914-02-9, name is 3,3-Dimethylindoline, molecular formula is C10H13N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of NaHC03 (5.41 g, 64.39 mmol) and 3,3-dimethylindoline (0.79 g, 5.37 mmol) in DCM (10 mL) was added acetyl chloride (0.76 mL, 10.73 mmol) dropwise at 0 C. The reaction was stirred at rt for 2 h, then filtered. The filtrate was concentrated in vacuo to give the title compound as a white solid (0.99 g, 97.1%). MS (ESI, pos. ion) m/z: 190 [M + H]+; NMR (CDCI3) delta (ppm): 8.11 (d, 1H), 7.13 (t, 1H), 7.06 (d, 1H), 6.97 (t, 1H), 3.70 (s, 2H), 2.15 (s, 3H), 1.29 (s, 6H).
The synthetic route of 1914-02-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem